Lung clearance of 99mTc-DTPA in systemic lupus erythematosus
The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease a...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2002-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600005 |
| _version_ | 1819129991510622208 |
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| author | P.T.R. Dalcin S.S.M. Barreto R.D. Cunha R.M. Xavier J.C.T. Brenol B.J. Marroni |
| author_facet | P.T.R. Dalcin S.S.M. Barreto R.D. Cunha R.M. Xavier J.C.T. Brenol B.J. Marroni |
| author_sort | P.T.R. Dalcin |
| collection | DOAJ |
| description | The early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85-92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease. |
| first_indexed | 2024-12-22T08:52:31Z |
| format | Article |
| id | doaj.art-5a1ccb977fe0477dbfc3f18c45665bb4 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-22T08:52:31Z |
| publishDate | 2002-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-5a1ccb977fe0477dbfc3f18c45665bb42022-12-21T18:31:56ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-06-0135666366810.1590/S0100-879X2002000600005Lung clearance of 99mTc-DTPA in systemic lupus erythematosusP.T.R. DalcinS.S.M. BarretoR.D. CunhaR.M. XavierJ.C.T. BrenolB.J. MarroniThe early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85-92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600005Pulmonary epithelial permeabilityLung clearanceTechnetium-99m-labeled diethylenetriamine pentaacetic acidSystemic lupus erythematosus |
| spellingShingle | P.T.R. Dalcin S.S.M. Barreto R.D. Cunha R.M. Xavier J.C.T. Brenol B.J. Marroni Lung clearance of 99mTc-DTPA in systemic lupus erythematosus Brazilian Journal of Medical and Biological Research Pulmonary epithelial permeability Lung clearance Technetium-99m-labeled diethylenetriamine pentaacetic acid Systemic lupus erythematosus |
| title | Lung clearance of 99mTc-DTPA in systemic lupus erythematosus |
| title_full | Lung clearance of 99mTc-DTPA in systemic lupus erythematosus |
| title_fullStr | Lung clearance of 99mTc-DTPA in systemic lupus erythematosus |
| title_full_unstemmed | Lung clearance of 99mTc-DTPA in systemic lupus erythematosus |
| title_short | Lung clearance of 99mTc-DTPA in systemic lupus erythematosus |
| title_sort | lung clearance of 99mtc dtpa in systemic lupus erythematosus |
| topic | Pulmonary epithelial permeability Lung clearance Technetium-99m-labeled diethylenetriamine pentaacetic acid Systemic lupus erythematosus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600005 |
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