Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis
Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-fu...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Magnetochemistry |
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| Online Access: | https://www.mdpi.com/2312-7481/9/7/187 |
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| author | Natália Andrýsková Paul Sourivong Melánia Babincová Peter Babinec Mária Šimaljaková |
| author_facet | Natália Andrýsková Paul Sourivong Melánia Babincová Peter Babinec Mária Šimaljaková |
| author_sort | Natália Andrýsková |
| collection | DOAJ |
| description | Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold promise for the development of new topical formulations for psoriasis treatment using dithranol. |
| first_indexed | 2024-03-11T00:53:46Z |
| format | Article |
| id | doaj.art-5a1e25a7d3074f278ba0135c51b34aeb |
| institution | Directory Open Access Journal |
| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-11T00:53:46Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-5a1e25a7d3074f278ba0135c51b34aeb2023-11-18T20:13:45ZengMDPI AGMagnetochemistry2312-74812023-07-019718710.3390/magnetochemistry9070187Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of PsoriasisNatália Andrýsková0Paul Sourivong1Melánia Babincová2Peter Babinec3Mária Šimaljaková4Department of Dermatovenereology, Faculty of Medicine, Comenius University and Bratislava University Hospital, Mickiewiczova 13, 813 69 Bratislava, SlovakiaDepartment of Radiation Oncology, Houston Methodist San Jacinto Hospital, 4021 Garth Road, Suite 105, Baytown, TX 77521, USADepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, SlovakiaDepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, SlovakiaDepartment of Dermatovenereology, Faculty of Medicine, Comenius University and Bratislava University Hospital, Mickiewiczova 13, 813 69 Bratislava, SlovakiaDithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold promise for the development of new topical formulations for psoriasis treatment using dithranol.https://www.mdpi.com/2312-7481/9/7/187psoriasismagnetic nanoparticlesphotostabilitydithranolcoaxial nanofibers |
| spellingShingle | Natália Andrýsková Paul Sourivong Melánia Babincová Peter Babinec Mária Šimaljaková Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis Magnetochemistry psoriasis magnetic nanoparticles photostability dithranol coaxial nanofibers |
| title | Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis |
| title_full | Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis |
| title_fullStr | Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis |
| title_full_unstemmed | Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis |
| title_short | Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis |
| title_sort | electrospun pcl pva coaxial nanofibers with embedded titanium dioxide and magnetic nanoparticles for stabilization and controlled release of dithranol for therapy of psoriasis |
| topic | psoriasis magnetic nanoparticles photostability dithranol coaxial nanofibers |
| url | https://www.mdpi.com/2312-7481/9/7/187 |
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