MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts

MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts

Abstract Background In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of pulmonary fibrosis. Our previous report showed that the Rac1-dependent...

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Bibliographic Details
Main Authors: Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang, Bing-Chang Chen
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Biomedical Science
Subjects:
CXCL12
CTGF
Pulmonary fibrosis
Lung fibroblasts
SMAD3
Online Access:http://link.springer.com/article/10.1186/s12929-018-0421-9

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