Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review
<i>Yersinia</i> spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely <i>Y. pestis</i>, <i>Y. enterocolitica</i> and <i>Y. pseudotuberculosis</i>. Since infective endocarditis (IE) i...
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MDPI AG
2021-02-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/6/1/19 |
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| author | Petros Ioannou Georgios Vougiouklakis Stella Baliou Eugenia Miliara Diamantis P. Kofteridis |
| author_facet | Petros Ioannou Georgios Vougiouklakis Stella Baliou Eugenia Miliara Diamantis P. Kofteridis |
| author_sort | Petros Ioannou |
| collection | DOAJ |
| description | <i>Yersinia</i> spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely <i>Y. pestis</i>, <i>Y. enterocolitica</i> and <i>Y. pseudotuberculosis</i>. Since infective endocarditis (IE) is rarely caused by <i>Yersinia</i>, the management of these infections can be problematic due to the lack of experience. The purpose of this study was to systematically review all published cases of IE by <i>Yersinia</i> species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 1 November 2020) for studies providing epidemiological, clinical and microbiological information as well as data on treatment and outcomes of IE caused by <i>Yersinia</i> species was performed. A total of 12 studies, containing data of 12 patients, were included. A prosthetic valve was present in 17% of patients. The mitral valve was the most commonly infected site, followed by the aortic valve. Fever, sepsis and embolic phenomena were common clinical signs, followed by heart failure. Aminoglycosides, cephalosporins and quinolones were the most commonly used antimicrobials. Clinical cure was noted in 83%, while overall mortality was 17%. This systematic review describes IE by <i>Yersinia</i> and provides information on patients’ epidemiology, clinical signs and the related therapeutic strategies and outcomes. |
| first_indexed | 2024-03-09T06:03:17Z |
| format | Article |
| id | doaj.art-5a22ee0851f3445d945b683513229810 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-09T06:03:17Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-5a22ee0851f3445d945b6835132298102023-12-03T12:07:10ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-02-01611910.3390/tropicalmed6010019Infective Endocarditis by <i>Yersinia</i> Species: A Systematic ReviewPetros Ioannou0Georgios Vougiouklakis1Stella Baliou2Eugenia Miliara3Diamantis P. Kofteridis4Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, 71110 Crete, GreeceDepartment of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, 71110 Crete, GreeceNational Hellenic Research Foundation, 11635 Athens, GreeceDepartment of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, 71110 Crete, GreeceDepartment of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, 71110 Crete, Greece<i>Yersinia</i> spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely <i>Y. pestis</i>, <i>Y. enterocolitica</i> and <i>Y. pseudotuberculosis</i>. Since infective endocarditis (IE) is rarely caused by <i>Yersinia</i>, the management of these infections can be problematic due to the lack of experience. The purpose of this study was to systematically review all published cases of IE by <i>Yersinia</i> species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 1 November 2020) for studies providing epidemiological, clinical and microbiological information as well as data on treatment and outcomes of IE caused by <i>Yersinia</i> species was performed. A total of 12 studies, containing data of 12 patients, were included. A prosthetic valve was present in 17% of patients. The mitral valve was the most commonly infected site, followed by the aortic valve. Fever, sepsis and embolic phenomena were common clinical signs, followed by heart failure. Aminoglycosides, cephalosporins and quinolones were the most commonly used antimicrobials. Clinical cure was noted in 83%, while overall mortality was 17%. This systematic review describes IE by <i>Yersinia</i> and provides information on patients’ epidemiology, clinical signs and the related therapeutic strategies and outcomes.https://www.mdpi.com/2414-6366/6/1/19endocarditissystematic review<i>Yersinia</i>antimicrobial susceptibility |
| spellingShingle | Petros Ioannou Georgios Vougiouklakis Stella Baliou Eugenia Miliara Diamantis P. Kofteridis Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review Tropical Medicine and Infectious Disease endocarditis systematic review <i>Yersinia</i> antimicrobial susceptibility |
| title | Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review |
| title_full | Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review |
| title_fullStr | Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review |
| title_full_unstemmed | Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review |
| title_short | Infective Endocarditis by <i>Yersinia</i> Species: A Systematic Review |
| title_sort | infective endocarditis by i yersinia i species a systematic review |
| topic | endocarditis systematic review <i>Yersinia</i> antimicrobial susceptibility |
| url | https://www.mdpi.com/2414-6366/6/1/19 |
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