Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet
The consumption of a diet high in fat and refined sugars has several health risks, including the development of cognitive decline and neurodegeneration. For women, menopause carries additional health risks that may interact with a high-fat diet in negative ways. Some symptoms of menopause, including...
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| Format: | Article |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00539/full |
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| author | Benjamin Zimmerman Benjamin Zimmerman Benjamin Zimmerman Payel Kundu Zheng Liu Zheng Liu Henryk F. Urbanski Henryk F. Urbanski Christopher D. Kroenke Christopher D. Kroenke Christopher D. Kroenke Steven G. Kohama Cynthia L. Bethea Cynthia L. Bethea Cynthia L. Bethea Jacob Raber Jacob Raber Jacob Raber |
| author_facet | Benjamin Zimmerman Benjamin Zimmerman Benjamin Zimmerman Payel Kundu Zheng Liu Zheng Liu Henryk F. Urbanski Henryk F. Urbanski Christopher D. Kroenke Christopher D. Kroenke Christopher D. Kroenke Steven G. Kohama Cynthia L. Bethea Cynthia L. Bethea Cynthia L. Bethea Jacob Raber Jacob Raber Jacob Raber |
| author_sort | Benjamin Zimmerman |
| collection | DOAJ |
| description | The consumption of a diet high in fat and refined sugars has several health risks, including the development of cognitive decline and neurodegeneration. For women, menopause carries additional health risks that may interact with a high-fat diet in negative ways. Some symptoms of menopause, including cognitive impairments, can be modulated by hormone replacement therapy (HRT), but the hormonal formulation and the timing of the treatment relative to the onset of menopause are critical factors determining its efficacy. Little is known about how obesogenic, high-fat, high-sugar diets interact with HRT in menopause to affect cognition and neurodegeneration. Given the high prevalence of the consumption of an obesogenic Western-style diet, understanding how the effects of HRT are modulated by an obesogenic diet is critical for developing optimized therapeutic strategies for peri- and post-menopausal women. In this study, we investigated by magnetic resonance imaging (MRI) the effects of either immediate or delayed estradiol hormone therapy on cognition and neuroanatomy following ovo-hysterectomy (OvH) of aged, female rhesus macaques on an obesogenic diet. The macaques were followed for 2.5 years after ovo-hysterectomy, with four time points at which anatomical MRIs were acquired. Analysis of hippocampal volumes revealed an interaction between time point and treatment; hippocampal volumes in the delayed estrogen group, but not the immediate estrogen group, increased over time compared to those in untreated controls. Performance on a hippocampal-dependent spatial maze task showed improved performance in estrogen treated animals compared to OvH macaques given placebo. These results indicate that HRT may contribute to beneficial cognitive outcomes after menopause under an obesogenic diet. |
| first_indexed | 2024-12-19T10:32:30Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T10:32:30Z |
| publishDate | 2020-06-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-5a233bb8b46f4f0c82d1263e2f7af86f2022-12-21T20:25:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00539540457Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic DietBenjamin Zimmerman0Benjamin Zimmerman1Benjamin Zimmerman2Payel Kundu3Zheng Liu4Zheng Liu5Henryk F. Urbanski6Henryk F. Urbanski7Christopher D. Kroenke8Christopher D. Kroenke9Christopher D. Kroenke10Steven G. Kohama11Cynthia L. Bethea12Cynthia L. Bethea13Cynthia L. Bethea14Jacob Raber15Jacob Raber16Jacob Raber17Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United StatesDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United StatesBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United StatesAdvanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesAdvanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United StatesDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesDivision of Reproductive and Developmental Science, Oregon National Primate Research Center, Beaverton, OR, United StatesDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, United StatesDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United StatesDepartments of Neurology and Radiation Medicine, Oregon Health and Science University, Portland, OR, United StatesThe consumption of a diet high in fat and refined sugars has several health risks, including the development of cognitive decline and neurodegeneration. For women, menopause carries additional health risks that may interact with a high-fat diet in negative ways. Some symptoms of menopause, including cognitive impairments, can be modulated by hormone replacement therapy (HRT), but the hormonal formulation and the timing of the treatment relative to the onset of menopause are critical factors determining its efficacy. Little is known about how obesogenic, high-fat, high-sugar diets interact with HRT in menopause to affect cognition and neurodegeneration. Given the high prevalence of the consumption of an obesogenic Western-style diet, understanding how the effects of HRT are modulated by an obesogenic diet is critical for developing optimized therapeutic strategies for peri- and post-menopausal women. In this study, we investigated by magnetic resonance imaging (MRI) the effects of either immediate or delayed estradiol hormone therapy on cognition and neuroanatomy following ovo-hysterectomy (OvH) of aged, female rhesus macaques on an obesogenic diet. The macaques were followed for 2.5 years after ovo-hysterectomy, with four time points at which anatomical MRIs were acquired. Analysis of hippocampal volumes revealed an interaction between time point and treatment; hippocampal volumes in the delayed estrogen group, but not the immediate estrogen group, increased over time compared to those in untreated controls. Performance on a hippocampal-dependent spatial maze task showed improved performance in estrogen treated animals compared to OvH macaques given placebo. These results indicate that HRT may contribute to beneficial cognitive outcomes after menopause under an obesogenic diet.https://www.frontiersin.org/article/10.3389/fneur.2020.00539/fullmenopausehormone replacement therapyobesogenic dietneurodegenerationaging |
| spellingShingle | Benjamin Zimmerman Benjamin Zimmerman Benjamin Zimmerman Payel Kundu Zheng Liu Zheng Liu Henryk F. Urbanski Henryk F. Urbanski Christopher D. Kroenke Christopher D. Kroenke Christopher D. Kroenke Steven G. Kohama Cynthia L. Bethea Cynthia L. Bethea Cynthia L. Bethea Jacob Raber Jacob Raber Jacob Raber Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet Frontiers in Neurology menopause hormone replacement therapy obesogenic diet neurodegeneration aging |
| title | Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet |
| title_full | Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet |
| title_fullStr | Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet |
| title_full_unstemmed | Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet |
| title_short | Longitudinal Effects of Immediate and Delayed Estradiol on Cognitive Performance in a Spatial Maze and Hippocampal Volume in Menopausal Macaques Under an Obesogenic Diet |
| title_sort | longitudinal effects of immediate and delayed estradiol on cognitive performance in a spatial maze and hippocampal volume in menopausal macaques under an obesogenic diet |
| topic | menopause hormone replacement therapy obesogenic diet neurodegeneration aging |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00539/full |
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