Sph2<sub>(176–191)</sub> and Sph2<sub>(446–459)</sub>: Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

Sph2<sub>(176–191)</sub> and Sph2<sub>(446–459)</sub>: Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by bacteria sphingomyelinases may contribute to the pathogenesis of infection. Among <i>Leptospira</i> spp., there are five sphingomyelinases exclusively expressed by pathogenic leptospires, in which Sph2...

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Bibliographic Details
Main Authors: Laura Sant’Anna Ataides, Fernanda de Moraes Maia, Fernando Paiva Conte, Lourdes Isaac, Angela Silva Barbosa, Josué da Costa Lima-Junior, Kátia Eliane Santos Avelar, Rodrigo Nunes Rodrigues-da-Silva
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Vaccines
Subjects:
leptospirosis
B-cell epitope
immunoinformatic
Online Access:https://www.mdpi.com/2076-393X/11/2/359

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