Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy
BackgroundAt present, immunotherapy has become an important treatment for lung cancer. With the widespread use of immune checkpoint inhibitors (ICIs), we must be strict with the emergence of immune related adverse events (irAEs). There are also some patients who do not respond to immunotherapy. Howe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.923531/full |
| _version_ | 1811297007843672064 |
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| author | Ni Zhao Ye Yi Wen Cao Xiao Fu Nan Mei Chunli Li |
| author_facet | Ni Zhao Ye Yi Wen Cao Xiao Fu Nan Mei Chunli Li |
| author_sort | Ni Zhao |
| collection | DOAJ |
| description | BackgroundAt present, immunotherapy has become an important treatment for lung cancer. With the widespread use of immune checkpoint inhibitors (ICIs), we must be strict with the emergence of immune related adverse events (irAEs). There are also some patients who do not respond to immunotherapy. However, there was no biomarkers to predict the safety and efficacy of immunotherapy. The selection of immunotherapy beneficiaries contributes to improving the efficacy and safety of lung cancer treatment.MethodThe electronic medical records of 221 lung cancer patients with complete clinical data who received immunotherapy from the First Affiliated Hospital of Xi ‘an Jiaotong University from November 2020 to October 2021 were collected and followed up. IBM SPSS Statistic 26.0 and R 4.1.2 software were used for statistical analysis and mapping.Results1. A total of 221 lung cancer patients receiving immunotherapy were included in the study. Higher baseline levels of IL-1β (7.88 vs 16.16pg/mL, P=0.041) and IL-2 (1.28 vs 2.48pg/mL, P=0.001) were significantly associated with irAEs. Higher levels of IL-5 (2.64 vs 5.68pg/mL, P=0.013), IFN-α (1.70 vs 3.56pg/mL, P=0.004) and IFN-γ (6.14 vs 21.31pg/mL, P=0.022) after the first cycle therapy were associated with irAEs. There was no statistical significance between cytokines and irAEs after the second cycle therapy. Higher IL-5 levels in peripheral blood (9.50 vs 3.57pg/mL, P=0.032) were associated with the occurrence of irAEs after the third cycle therapy. 2.The efficacy of immunotherapy was assessed in 142 lung cancer patients. There was no statistical significance between baseline cytokine levels and clinical benefit. After the first cycle therapy, the level of serum cytokines had no statistical significance with the occurrence of immunotherapy clinical benefit. Lower serum levels of IL-10 (2.66 vs 1.26pg/mL, P=0.016) and IL-17 (8.47 vs 2.81pg/mL, P=0.015) were associated with clinical benefit after the second cycle therapy. Lower serum levels of IL-6 (10.19 vs 41.07pg/mL, P=0.013) and IL-8 (8.01 vs 17.22pg/mL, P=0.039) were associated with clinical benefit of immunotherapy after the third cycle therapy.Conclusion1. Baseline IL-1β and IL-2 levels in peripheral blood were associated with the occurrence of irAEs in lung cancer patients. The levels of IL-5, IFN-α and IFN-γ during treatment were associated with irAEs. 2. Baseline cytokine levels in peripheral blood were not associated with immunotherapy efficacy. The levels of IL-6, IL-8, IL-10, and IL-17 levels during treatment were associated with immunotherapy efficacy. |
| first_indexed | 2024-04-13T05:57:47Z |
| format | Article |
| id | doaj.art-5a249561106e4d368dff181eb3a5aee9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T05:57:47Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-5a249561106e4d368dff181eb3a5aee92022-12-22T02:59:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.923531923531Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapyNi Zhao0Ye Yi1Wen Cao2Xiao Fu3Nan Mei4Chunli Li5Department of Medical Oncology, The First Affiliated Hospital of Xi’’an Jiaotong University, Xi’an, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’’an Jiaotong University, Xi’an, ChinaDepartment of Hematology. The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’’an Jiaotong University, Xi’an, ChinaBackgroundAt present, immunotherapy has become an important treatment for lung cancer. With the widespread use of immune checkpoint inhibitors (ICIs), we must be strict with the emergence of immune related adverse events (irAEs). There are also some patients who do not respond to immunotherapy. However, there was no biomarkers to predict the safety and efficacy of immunotherapy. The selection of immunotherapy beneficiaries contributes to improving the efficacy and safety of lung cancer treatment.MethodThe electronic medical records of 221 lung cancer patients with complete clinical data who received immunotherapy from the First Affiliated Hospital of Xi ‘an Jiaotong University from November 2020 to October 2021 were collected and followed up. IBM SPSS Statistic 26.0 and R 4.1.2 software were used for statistical analysis and mapping.Results1. A total of 221 lung cancer patients receiving immunotherapy were included in the study. Higher baseline levels of IL-1β (7.88 vs 16.16pg/mL, P=0.041) and IL-2 (1.28 vs 2.48pg/mL, P=0.001) were significantly associated with irAEs. Higher levels of IL-5 (2.64 vs 5.68pg/mL, P=0.013), IFN-α (1.70 vs 3.56pg/mL, P=0.004) and IFN-γ (6.14 vs 21.31pg/mL, P=0.022) after the first cycle therapy were associated with irAEs. There was no statistical significance between cytokines and irAEs after the second cycle therapy. Higher IL-5 levels in peripheral blood (9.50 vs 3.57pg/mL, P=0.032) were associated with the occurrence of irAEs after the third cycle therapy. 2.The efficacy of immunotherapy was assessed in 142 lung cancer patients. There was no statistical significance between baseline cytokine levels and clinical benefit. After the first cycle therapy, the level of serum cytokines had no statistical significance with the occurrence of immunotherapy clinical benefit. Lower serum levels of IL-10 (2.66 vs 1.26pg/mL, P=0.016) and IL-17 (8.47 vs 2.81pg/mL, P=0.015) were associated with clinical benefit after the second cycle therapy. Lower serum levels of IL-6 (10.19 vs 41.07pg/mL, P=0.013) and IL-8 (8.01 vs 17.22pg/mL, P=0.039) were associated with clinical benefit of immunotherapy after the third cycle therapy.Conclusion1. Baseline IL-1β and IL-2 levels in peripheral blood were associated with the occurrence of irAEs in lung cancer patients. The levels of IL-5, IFN-α and IFN-γ during treatment were associated with irAEs. 2. Baseline cytokine levels in peripheral blood were not associated with immunotherapy efficacy. The levels of IL-6, IL-8, IL-10, and IL-17 levels during treatment were associated with immunotherapy efficacy.https://www.frontiersin.org/articles/10.3389/fonc.2022.923531/fullbiomarkerscytokinesimmunotherapylung cancerimmune related adverse events |
| spellingShingle | Ni Zhao Ye Yi Wen Cao Xiao Fu Nan Mei Chunli Li Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy Frontiers in Oncology biomarkers cytokines immunotherapy lung cancer immune related adverse events |
| title | Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy |
| title_full | Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy |
| title_fullStr | Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy |
| title_full_unstemmed | Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy |
| title_short | Serum cytokine levels for predicting immune-related adverse events and the clinical response in lung cancer treated with immunotherapy |
| title_sort | serum cytokine levels for predicting immune related adverse events and the clinical response in lung cancer treated with immunotherapy |
| topic | biomarkers cytokines immunotherapy lung cancer immune related adverse events |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.923531/full |
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