A review of advanced hydrogels for cartilage tissue engineering
With the increase in weight and age of the population, the consumption of tobacco, inappropriate foods, and the reduction of sports activities in recent years, bone and joint diseases such as osteoarthritis (OA) have become more common in the world. From the past until now, various treatment strateg...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1340893/full |
| _version_ | 1797321026802024448 |
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| author | Mojtaba Ansari Ahmad Darvishi Alireza Sabzevari |
| author_facet | Mojtaba Ansari Ahmad Darvishi Alireza Sabzevari |
| author_sort | Mojtaba Ansari |
| collection | DOAJ |
| description | With the increase in weight and age of the population, the consumption of tobacco, inappropriate foods, and the reduction of sports activities in recent years, bone and joint diseases such as osteoarthritis (OA) have become more common in the world. From the past until now, various treatment strategies (e.g., microfracture treatment, Autologous Chondrocyte Implantation (ACI), and Mosaicplasty) have been investigated and studied for the prevention and treatment of this disease. However, these methods face problems such as being invasive, not fully repairing the tissue, and damaging the surrounding tissues. Tissue engineering, including cartilage tissue engineering, is one of the minimally invasive, innovative, and effective methods for the treatment and regeneration of damaged cartilage, which has attracted the attention of scientists in the fields of medicine and biomaterials engineering in the past several years. Hydrogels of different types with diverse properties have become desirable candidates for engineering and treating cartilage tissue. They can cover most of the shortcomings of other treatment methods and cause the least secondary damage to the patient. Besides using hydrogels as an ideal strategy, new drug delivery and treatment methods, such as targeted drug delivery and treatment through mechanical signaling, have been studied as interesting strategies. In this study, we review and discuss various types of hydrogels, biomaterials used for hydrogel manufacturing, cartilage-targeting drug delivery, and mechanosignaling as modern strategies for cartilage treatment. |
| first_indexed | 2024-03-08T04:51:34Z |
| format | Article |
| id | doaj.art-5a24df83d25c46d69b5b3792abdaeb84 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T04:51:34Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5a24df83d25c46d69b5b3792abdaeb842024-02-08T04:58:07ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13408931340893A review of advanced hydrogels for cartilage tissue engineeringMojtaba AnsariAhmad DarvishiAlireza SabzevariWith the increase in weight and age of the population, the consumption of tobacco, inappropriate foods, and the reduction of sports activities in recent years, bone and joint diseases such as osteoarthritis (OA) have become more common in the world. From the past until now, various treatment strategies (e.g., microfracture treatment, Autologous Chondrocyte Implantation (ACI), and Mosaicplasty) have been investigated and studied for the prevention and treatment of this disease. However, these methods face problems such as being invasive, not fully repairing the tissue, and damaging the surrounding tissues. Tissue engineering, including cartilage tissue engineering, is one of the minimally invasive, innovative, and effective methods for the treatment and regeneration of damaged cartilage, which has attracted the attention of scientists in the fields of medicine and biomaterials engineering in the past several years. Hydrogels of different types with diverse properties have become desirable candidates for engineering and treating cartilage tissue. They can cover most of the shortcomings of other treatment methods and cause the least secondary damage to the patient. Besides using hydrogels as an ideal strategy, new drug delivery and treatment methods, such as targeted drug delivery and treatment through mechanical signaling, have been studied as interesting strategies. In this study, we review and discuss various types of hydrogels, biomaterials used for hydrogel manufacturing, cartilage-targeting drug delivery, and mechanosignaling as modern strategies for cartilage treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1340893/fullcartilage tissue engineeringinjectable hydrogelsosteoarthritis (OA)drug deliverymechanobiology |
| spellingShingle | Mojtaba Ansari Ahmad Darvishi Alireza Sabzevari A review of advanced hydrogels for cartilage tissue engineering Frontiers in Bioengineering and Biotechnology cartilage tissue engineering injectable hydrogels osteoarthritis (OA) drug delivery mechanobiology |
| title | A review of advanced hydrogels for cartilage tissue engineering |
| title_full | A review of advanced hydrogels for cartilage tissue engineering |
| title_fullStr | A review of advanced hydrogels for cartilage tissue engineering |
| title_full_unstemmed | A review of advanced hydrogels for cartilage tissue engineering |
| title_short | A review of advanced hydrogels for cartilage tissue engineering |
| title_sort | review of advanced hydrogels for cartilage tissue engineering |
| topic | cartilage tissue engineering injectable hydrogels osteoarthritis (OA) drug delivery mechanobiology |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1340893/full |
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