Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia
<b>Background:</b> COVID-19 is a respiratory disease that eventually became a pandemic, with 300 million people infected around the world. Alongside the improvement in COVID-19 management and vaccine development, identifying biomarkers for COVID-19 has recently been reported to help in e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/5/260 |
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| author | Mashael Abujabal Mohamed A. Shalaby Layla Abdullah Amr S. Albanna Mohamed Elzoghby Ghadeer Ghazi Alahmadi Sidharth Kumar Sethi Mohamad-Hani Temsah Fadi Aljamaan Khalid Alhasan Jameela A. Kari |
| author_facet | Mashael Abujabal Mohamed A. Shalaby Layla Abdullah Amr S. Albanna Mohamed Elzoghby Ghadeer Ghazi Alahmadi Sidharth Kumar Sethi Mohamad-Hani Temsah Fadi Aljamaan Khalid Alhasan Jameela A. Kari |
| author_sort | Mashael Abujabal |
| collection | DOAJ |
| description | <b>Background:</b> COVID-19 is a respiratory disease that eventually became a pandemic, with 300 million people infected around the world. Alongside the improvement in COVID-19 management and vaccine development, identifying biomarkers for COVID-19 has recently been reported to help in early prediction and managing severe cases, which might improve outcomes. Our study aimed to find out if there is any correlation between clinical severity and elevated hematological and biochemical markers in COVID-19 patients and its effect on the outcome. <b>Methods:</b> We have collected retrospective data on socio-demographics, medical history, biomarkers, and disease outcomes from five hospitals and health institutions in the Kingdom of Saudi Arabia. <b>Results:</b> Pneumonia was the most common presentation of COVID-19 in our cohort. The presence of abnormal inflammatory biomarkers (D-dimer, CRP, troponin, LDH, ferritin, and t white blood cells) was significantly associated with unstable COVID-19 disease. In addition, patients with evidence of severe respiratory disease, particularly those who required mechanical ventilation, had higher biomarkers when compared to those with stable respiratory conditions (<i>p</i> < 0.001). <b>Conclusion:</b> Identifying biomarkers predicts outcomes for COVID-19 patients and may significantly help in their management. |
| first_indexed | 2024-03-11T03:15:23Z |
| format | Article |
| id | doaj.art-5a250a80a9c449d7a40f933ffadb9351 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-11T03:15:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-5a250a80a9c449d7a40f933ffadb93512023-11-18T03:34:08ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-04-018526010.3390/tropicalmed8050260Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi ArabiaMashael Abujabal0Mohamed A. Shalaby1Layla Abdullah2Amr S. Albanna3Mohamed Elzoghby4Ghadeer Ghazi Alahmadi5Sidharth Kumar Sethi6Mohamad-Hani Temsah7Fadi Aljamaan8Khalid Alhasan9Jameela A. Kari10Pediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi ArabiaPediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi ArabiaPediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 14611, Saudi ArabiaPediatric Intensive Care Unit, Pediatrics Department, College of Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi ArabiaDepartment of Pediatric, College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaKidney and Renal Transplant Institute, Medanta, The Medicity Hospital, Gurgaon 122001, IndiaPediatric Department, College of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaCritical Care Department, College of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaPediatric Department, College of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaPediatric Nephrology Unit, Faculty of Medicine and Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia<b>Background:</b> COVID-19 is a respiratory disease that eventually became a pandemic, with 300 million people infected around the world. Alongside the improvement in COVID-19 management and vaccine development, identifying biomarkers for COVID-19 has recently been reported to help in early prediction and managing severe cases, which might improve outcomes. Our study aimed to find out if there is any correlation between clinical severity and elevated hematological and biochemical markers in COVID-19 patients and its effect on the outcome. <b>Methods:</b> We have collected retrospective data on socio-demographics, medical history, biomarkers, and disease outcomes from five hospitals and health institutions in the Kingdom of Saudi Arabia. <b>Results:</b> Pneumonia was the most common presentation of COVID-19 in our cohort. The presence of abnormal inflammatory biomarkers (D-dimer, CRP, troponin, LDH, ferritin, and t white blood cells) was significantly associated with unstable COVID-19 disease. In addition, patients with evidence of severe respiratory disease, particularly those who required mechanical ventilation, had higher biomarkers when compared to those with stable respiratory conditions (<i>p</i> < 0.001). <b>Conclusion:</b> Identifying biomarkers predicts outcomes for COVID-19 patients and may significantly help in their management.https://www.mdpi.com/2414-6366/8/5/260biomarkersCOVID-19common prognostic biomarkers |
| spellingShingle | Mashael Abujabal Mohamed A. Shalaby Layla Abdullah Amr S. Albanna Mohamed Elzoghby Ghadeer Ghazi Alahmadi Sidharth Kumar Sethi Mohamad-Hani Temsah Fadi Aljamaan Khalid Alhasan Jameela A. Kari Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia Tropical Medicine and Infectious Disease biomarkers COVID-19 common prognostic biomarkers |
| title | Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia |
| title_full | Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia |
| title_fullStr | Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia |
| title_full_unstemmed | Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia |
| title_short | Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia |
| title_sort | common prognostic biomarkers and outcomes in patients with covid 19 infection in saudi arabia |
| topic | biomarkers COVID-19 common prognostic biomarkers |
| url | https://www.mdpi.com/2414-6366/8/5/260 |
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