A potent anti‐dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

A potent anti‐dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

Abstract Dengue virus (DENV), which consists of four serotypes (DENV1‐4), infects over 400 million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengue patients are cross‐reactive and poorly neutralizing. Rare neutralizing HMAbs are usually serotype‐s...

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Bibliographic Details
Main Authors: Guntur Fibriansah, Joanne L Tan, Scott A Smith, Adamberage R deAlwis, Thiam‐Seng Ng, Victor A Kostyuchenko, Kristie D Ibarra, Jiaqi Wang, Eva Harris, Aravinda deSilva, James E Crowe Jr, Shee‐Mei Lok
Format: Article
Language:English
Published: Springer Nature 2014-03-01
Series:EMBO Molecular Medicine
Subjects:
cryoEM
dengue virus
human antibody
neutralization
structure
Online Access:https://doi.org/10.1002/emmm.201303404

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