Anticancer Small-Molecule Agents Targeting Eukaryotic Elongation Factor 1A: State of the Art

Anticancer Small-Molecule Agents Targeting Eukaryotic Elongation Factor 1A: State of the Art

Eukaryotic elongation factor 1A (eEF1A) canonically delivers amino acyl tRNA to the ribosomal A site during the elongation stage of protein biosynthesis. Yet paradoxically, the oncogenic nature of this instrumental protein has long been recognized. Consistently, eEF1A has proven to be targeted by a...

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Bibliographic Details
Main Authors:	Han Zhang, Jiayou Cai, Siqi Yu, Bin Sun, Weicheng Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	International Journal of Molecular Sciences
Subjects:	anticancer eEF1A mechanism macrocycle heterocycle
Online Access:	https://www.mdpi.com/1422-0067/24/6/5184

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