Inhibition of macrophages inflammasome activation via autophagic degradation of HMGB1 by EGCG ameliorates HBV-induced liver injury and fibrosis

Inhibition of macrophages inflammasome activation via autophagic degradation of HMGB1 by EGCG ameliorates HBV-induced liver injury and fibrosis

BackgroundLiver fibrosis is a reversible wound-healing response that can lead to end-stage liver diseases without effective treatment, in which HBV infection is a major cause. However, the underlying mechanisms for the development of HBV-induced fibrosis remains elusive, and efficacious therapies fo...

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Bibliographic Details
Main Authors: Minjing He, Tianhao Chu, Ziteng Wang, Ying Feng, Runhan Shi, Muyang He, Siheng Feng, Lin Lu, Chen Cai, Fang Fang, Xuemin Zhang, Yi Liu, Bo Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
liver fibrosis
HBV
EGCG
NLRP3 inflammasome
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147379/full

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