Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases
Diagnosis-specific survival scores including a new score developed in 157 patients with brain metastases from small-cell lung cancer (SCLC) receiving whole-brain radiotherapy (WBRT) with 30 Gy in 10 fractions (WBRT-30-SCLC) were compared. Three prognostic groups were designed based on the 6-month su...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/2/233 |
| _version_ | 1797706516386545664 |
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| author | Dirk Rades Heinke C. Hansen Stefan Janssen Steven E. Schild |
| author_facet | Dirk Rades Heinke C. Hansen Stefan Janssen Steven E. Schild |
| author_sort | Dirk Rades |
| collection | DOAJ |
| description | Diagnosis-specific survival scores including a new score developed in 157 patients with brain metastases from small-cell lung cancer (SCLC) receiving whole-brain radiotherapy (WBRT) with 30 Gy in 10 fractions (WBRT-30-SCLC) were compared. Three prognostic groups were designed based on the 6-month survival probabilities of significant or almost significant factors, (age, performance score, number of brain metastases, extra-cerebral metastasis). Six-month survival rates were 6% (6⁻11 points), 44% (12⁻14 points) and 86% (16⁻19 points). The WBRT-30-SCLC was compared to three disease-specific scores for brain metastasis from SCLC, the original and updated diagnosis-specific graded prognostic assessment DS-GPA classifications and the Rades-SCLC. Positive predictive values (PPVs) used to correctly predict death ≤6 months were 94% (WBRT-30-SCLC), 88% (original DS-GPA), 88% (updated DS-GPA) and 100% (Rades-SCLC). PPVs to predict survival ≥6 months were 86%, 75%, 76% and 100%. For WBRT-30-SCLC and Rades-SCLC, differences between poor and intermediate prognoses groups and between intermediate and favorable prognoses groups were significant. For both DS-GPA classifications, only the difference between poor and intermediate prognoses groups was significant. Of these disease-specific tools, Rades-SCLC appeared to be the most accurate in identifying patients dying ≤6 months and patients surviving ≥6 months after irradiation, followed by the new WBRT-30-SCLC and the DS-GPA classifications. |
| first_indexed | 2024-03-12T05:53:27Z |
| format | Article |
| id | doaj.art-5a2c1c8b14f4413fb97e1e8fe62cae97 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:53:27Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a2c1c8b14f4413fb97e1e8fe62cae972023-09-03T04:54:29ZengMDPI AGCancers2072-66942019-02-0111223310.3390/cancers11020233cancers11020233Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain MetastasesDirk Rades0Heinke C. Hansen1Stefan Janssen2Steven E. Schild3Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, GermanyDepartment of Radiation Oncology, University of Lübeck, 23562 Lübeck, GermanyDepartment of Radiation Oncology, University of Lübeck, 23562 Lübeck, GermanyDepartment of Radiation Oncology, Mayo Clinic, Scottsdale, AZ 85259, USADiagnosis-specific survival scores including a new score developed in 157 patients with brain metastases from small-cell lung cancer (SCLC) receiving whole-brain radiotherapy (WBRT) with 30 Gy in 10 fractions (WBRT-30-SCLC) were compared. Three prognostic groups were designed based on the 6-month survival probabilities of significant or almost significant factors, (age, performance score, number of brain metastases, extra-cerebral metastasis). Six-month survival rates were 6% (6⁻11 points), 44% (12⁻14 points) and 86% (16⁻19 points). The WBRT-30-SCLC was compared to three disease-specific scores for brain metastasis from SCLC, the original and updated diagnosis-specific graded prognostic assessment DS-GPA classifications and the Rades-SCLC. Positive predictive values (PPVs) used to correctly predict death ≤6 months were 94% (WBRT-30-SCLC), 88% (original DS-GPA), 88% (updated DS-GPA) and 100% (Rades-SCLC). PPVs to predict survival ≥6 months were 86%, 75%, 76% and 100%. For WBRT-30-SCLC and Rades-SCLC, differences between poor and intermediate prognoses groups and between intermediate and favorable prognoses groups were significant. For both DS-GPA classifications, only the difference between poor and intermediate prognoses groups was significant. Of these disease-specific tools, Rades-SCLC appeared to be the most accurate in identifying patients dying ≤6 months and patients surviving ≥6 months after irradiation, followed by the new WBRT-30-SCLC and the DS-GPA classifications.https://www.mdpi.com/2072-6694/11/2/233brain metastasissmall-cell lung cancerwhole-brain radiotherapydiagnosis-specific survival scorespositive predictive values |
| spellingShingle | Dirk Rades Heinke C. Hansen Stefan Janssen Steven E. Schild Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases Cancers brain metastasis small-cell lung cancer whole-brain radiotherapy diagnosis-specific survival scores positive predictive values |
| title | Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases |
| title_full | Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases |
| title_fullStr | Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases |
| title_full_unstemmed | Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases |
| title_short | Comparison of Diagnosis-Specific Survival Scores for Patients with Small-Cell Lung Cancer Irradiated for Brain Metastases |
| title_sort | comparison of diagnosis specific survival scores for patients with small cell lung cancer irradiated for brain metastases |
| topic | brain metastasis small-cell lung cancer whole-brain radiotherapy diagnosis-specific survival scores positive predictive values |
| url | https://www.mdpi.com/2072-6694/11/2/233 |
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