Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast
Abstract Background In recent years, spectral CT-derived liver fat quantification method named multi-material decomposition (MMD) is playing an increasingly important role as an imaging biomarker of hepatic steatosis. However, there are various measurement ways with various results among different r...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | BMC Medical Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12880-024-01215-6 |
| _version_ | 1797272757802631168 |
|---|---|
| author | Liuhong Zhu Funan Wang Heqing Wang Jinhui Zhang Anjie Xie Jinkui Pei Jianjun Zhou Hao Liu |
| author_facet | Liuhong Zhu Funan Wang Heqing Wang Jinhui Zhang Anjie Xie Jinkui Pei Jianjun Zhou Hao Liu |
| author_sort | Liuhong Zhu |
| collection | DOAJ |
| description | Abstract Background In recent years, spectral CT-derived liver fat quantification method named multi-material decomposition (MMD) is playing an increasingly important role as an imaging biomarker of hepatic steatosis. However, there are various measurement ways with various results among different researches, and the impact of measurement methods on the research results is unknown. The aim of this study is to evaluate the reproducibility of liver fat volume fraction (FVF) using MMD algorithm in nonalcoholic fatty liver disease (NAFLD) patients when taking blood vessel, location, and iodine contrast into account during measurement. Methods This retrospective study was approved by the institutional ethics committee, and the requirement for informed consent was waived because of the retrospective nature of the study. 101 patients with NAFLD were enrolled in this study. Participants underwent non-contrast phase (NCP) and two-phase enhanced CT scanning (late arterial phase (LAP) and portal vein phase (PVP)) with spectral mode. Regions of interest (ROIs) were placed at right posterior lobe (RPL), right anterior lobe (RAL) and left lateral lobe (LLL) to obtain FVF values on liver fat images without and with the reference of enhanced CT images. The differences of FVF values measured under different conditions (ROI locations, with/without enhancement reference, NCP and enhanced phases) were compared. Friedman test was used to compare FVF values among three phases for each lobe, while the consistency of FVF values was assessed between each two phases using Bland–Altman analysis. Results Significant difference was found between FVF values obtained without and with the reference of enhanced CT images. There was no significant difference about FVF values obtained from NCP images under the reference of enhanced CT images between any two lobes or among three lobes. The FVF value increased after the contrast injection, and there were significant differences in the FVF values among three scanning phases. Poor consistencies of FVF values between each two phases were found in each lobe by Bland–Altman analysis. Conclusion MMD algorithm quantifying hepatic fat was reproducible among different lobes, while was influenced by blood vessel and iodine contrast. |
| first_indexed | 2024-03-07T14:34:40Z |
| format | Article |
| id | doaj.art-5a2ce6f5957643d49f76020cee1cced1 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-03-07T14:34:40Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-5a2ce6f5957643d49f76020cee1cced12024-03-05T20:43:52ZengBMCBMC Medical Imaging1471-23422024-02-0124111010.1186/s12880-024-01215-6Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrastLiuhong Zhu0Funan Wang1Heqing Wang2Jinhui Zhang3Anjie Xie4Jinkui Pei5Jianjun Zhou6Hao Liu7Department of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital (Xiamen), Fudan UniversityDepartment of Radiology, Zhongshan Hospital Fudan UniversityAbstract Background In recent years, spectral CT-derived liver fat quantification method named multi-material decomposition (MMD) is playing an increasingly important role as an imaging biomarker of hepatic steatosis. However, there are various measurement ways with various results among different researches, and the impact of measurement methods on the research results is unknown. The aim of this study is to evaluate the reproducibility of liver fat volume fraction (FVF) using MMD algorithm in nonalcoholic fatty liver disease (NAFLD) patients when taking blood vessel, location, and iodine contrast into account during measurement. Methods This retrospective study was approved by the institutional ethics committee, and the requirement for informed consent was waived because of the retrospective nature of the study. 101 patients with NAFLD were enrolled in this study. Participants underwent non-contrast phase (NCP) and two-phase enhanced CT scanning (late arterial phase (LAP) and portal vein phase (PVP)) with spectral mode. Regions of interest (ROIs) were placed at right posterior lobe (RPL), right anterior lobe (RAL) and left lateral lobe (LLL) to obtain FVF values on liver fat images without and with the reference of enhanced CT images. The differences of FVF values measured under different conditions (ROI locations, with/without enhancement reference, NCP and enhanced phases) were compared. Friedman test was used to compare FVF values among three phases for each lobe, while the consistency of FVF values was assessed between each two phases using Bland–Altman analysis. Results Significant difference was found between FVF values obtained without and with the reference of enhanced CT images. There was no significant difference about FVF values obtained from NCP images under the reference of enhanced CT images between any two lobes or among three lobes. The FVF value increased after the contrast injection, and there were significant differences in the FVF values among three scanning phases. Poor consistencies of FVF values between each two phases were found in each lobe by Bland–Altman analysis. Conclusion MMD algorithm quantifying hepatic fat was reproducible among different lobes, while was influenced by blood vessel and iodine contrast.https://doi.org/10.1186/s12880-024-01215-6Multi-material decomposition (MMD)Liver fat quantificationFat volume fraction (FVF)Nonalcoholic fatty liver disease (NAFLD) |
| spellingShingle | Liuhong Zhu Funan Wang Heqing Wang Jinhui Zhang Anjie Xie Jinkui Pei Jianjun Zhou Hao Liu Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast BMC Medical Imaging Multi-material decomposition (MMD) Liver fat quantification Fat volume fraction (FVF) Nonalcoholic fatty liver disease (NAFLD) |
| title | Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast |
| title_full | Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast |
| title_fullStr | Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast |
| title_full_unstemmed | Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast |
| title_short | Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast |
| title_sort | liver fat volume fraction measurements based on multi material decomposition algorithm in patients with nonalcoholic fatty liver disease the influences of blood vessel location and iodine contrast |
| topic | Multi-material decomposition (MMD) Liver fat quantification Fat volume fraction (FVF) Nonalcoholic fatty liver disease (NAFLD) |
| url | https://doi.org/10.1186/s12880-024-01215-6 |
| work_keys_str_mv | AT liuhongzhu liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT funanwang liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT heqingwang liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT jinhuizhang liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT anjiexie liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT jinkuipei liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT jianjunzhou liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast AT haoliu liverfatvolumefractionmeasurementsbasedonmultimaterialdecompositionalgorithminpatientswithnonalcoholicfattyliverdiseasetheinfluencesofbloodvessellocationandiodinecontrast |