Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis
Abstract Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control. Resistance mutations in katG (for INH) and rpoB (RIF) genes often come with fitness costs. To overcome these costs,...
Main Authors: | Gary Napier, Susana Campino, Jody E. Phelan, Taane G. Clark |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-01-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-27516-4 |
Similar Items
-
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis
by: Wouter Deelder, et al.
Published: (2022-01-01) -
Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis
by: Linfeng Wang, et al.
Published: (2023-10-01) -
Comparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data
by: Gary Napier, et al.
Published: (2023-07-01) -
Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host
by: Paula Josefina Gómez-González, et al.
Published: (2023-10-01) -
Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data
by: Wouter Deelder, et al.
Published: (2019-09-01)