Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831)
The data presented illustrated the in vitro anti-proliferative effect of the PSG toxin from the cuttlefish, Sepia pharaonis. The cytostatic potentials of the PSG toxin were determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) exhibited commendable inhibition of the migra...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917302019 |
| _version_ | 1811208606282940416 |
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| author | Ramachandran Karthik Venkatesan Manigandan Kumar Ebenezar Raghavan Vijayashree Ramachandran Saravanan |
| author_facet | Ramachandran Karthik Venkatesan Manigandan Kumar Ebenezar Raghavan Vijayashree Ramachandran Saravanan |
| author_sort | Ramachandran Karthik |
| collection | DOAJ |
| description | The data presented illustrated the in vitro anti-proliferative effect of the PSG toxin from the cuttlefish, Sepia pharaonis. The cytostatic potentials of the PSG toxin were determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) exhibited commendable inhibition of the migration of lymphocytes across the agarose gel matrix under the presence of lipopolysaccharide mitogen, with a mean migration index of 0.625. The cytotoxicity of the PSG toxin against selected cancer cell lines was determined using the MTT assay. The PSG toxin exhibited dose-dependent cytotoxicity against the MCF-7 breast cancer cells followed by KB (oral), HeLa (cervical) and A549 (lung) cancer cell lines. The PSG toxin also exhibited proportional release of LDH leakage by mitochondrial damage with an IC50 of 13.85 μM against MCF-7 breast cancer cells. The in vitro anticancer activity of the PSG toxin against the selected cell lines was evaluated by Karthik et al. (2017) [1]. Keywords: PSG toxin, Anticancer, Anti-proliferative, Breast cancer, MTT assay, LDH leakage assay |
| first_indexed | 2024-04-12T04:24:28Z |
| format | Article |
| id | doaj.art-5a2f88d6d7134c2eb5ae0b69a60c01dd |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-12T04:24:28Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-5a2f88d6d7134c2eb5ae0b69a60c01dd2022-12-22T03:48:08ZengElsevierData in Brief2352-34092017-08-0113295300Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831)Ramachandran Karthik0Venkatesan Manigandan1Kumar Ebenezar2Raghavan Vijayashree3Ramachandran Saravanan4Department of Medical Biotechnology, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaDepartment of Medical Biotechnology, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaDepartment of Pathology, Chettinad Hospital and Research Institute, Kelambakkam 603103, Tamil Nadu, IndiaFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India; Corresponding author.The data presented illustrated the in vitro anti-proliferative effect of the PSG toxin from the cuttlefish, Sepia pharaonis. The cytostatic potentials of the PSG toxin were determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) exhibited commendable inhibition of the migration of lymphocytes across the agarose gel matrix under the presence of lipopolysaccharide mitogen, with a mean migration index of 0.625. The cytotoxicity of the PSG toxin against selected cancer cell lines was determined using the MTT assay. The PSG toxin exhibited dose-dependent cytotoxicity against the MCF-7 breast cancer cells followed by KB (oral), HeLa (cervical) and A549 (lung) cancer cell lines. The PSG toxin also exhibited proportional release of LDH leakage by mitochondrial damage with an IC50 of 13.85 μM against MCF-7 breast cancer cells. The in vitro anticancer activity of the PSG toxin against the selected cell lines was evaluated by Karthik et al. (2017) [1]. Keywords: PSG toxin, Anticancer, Anti-proliferative, Breast cancer, MTT assay, LDH leakage assayhttp://www.sciencedirect.com/science/article/pii/S2352340917302019 |
| spellingShingle | Ramachandran Karthik Venkatesan Manigandan Kumar Ebenezar Raghavan Vijayashree Ramachandran Saravanan Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) Data in Brief |
| title | Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) |
| title_full | Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) |
| title_fullStr | Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) |
| title_full_unstemmed | Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) |
| title_short | Data supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831) |
| title_sort | data supporting the anticancer activity of posterior salivary gland psg toxin from the cuttlefish sepia pharaonis ehrenberg 1831 |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917302019 |
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