The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19
Bifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human stud...
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9219 |
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| author | Venera Z. Nezametdinova Roman A. Yunes Marina S. Dukhinova Maria G. Alekseeva Valery N. Danilenko |
| author_facet | Venera Z. Nezametdinova Roman A. Yunes Marina S. Dukhinova Maria G. Alekseeva Valery N. Danilenko |
| author_sort | Venera Z. Nezametdinova |
| collection | DOAJ |
| description | Bifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human studies. A possible candidate for this role has been discovered recently. The PFNA cluster, consisting of five core genes, <i>pkb2</i>, <i>fn3</i>, <i>aaa-atp</i>, <i>duf58</i>, <i>tgm</i>, has been found in all gut-dwelling autochthonous bifidobacterial species of humans. The sensory region of the species-specific serine-threonine protein kinase (PKB2), the transmembrane region of the microbial transglutaminase (TGM), and the type-III fibronectin domain-containing protein (FN3) encoded by the I gene imply that the PFNA cluster might be implicated in the interaction between bacteria and the host immune system. Moreover, the FN3 protein encoded by one of the genes making up the PFNA cluster, contains domains and motifs of cytokine receptors capable of selectively binding TNF-α. The PFNA cluster could play an important role for sensing signals of the immune system. Among the practical implications of this finding is the creation of anti-inflammatory drugs aimed at alleviating cytokine storms, one of the dire consequences resulting from SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T08:11:37Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:11:37Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5a322c8354024b89b4d2e881b6cf2eb12023-11-22T10:40:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217921910.3390/ijms22179219The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19Venera Z. Nezametdinova0Roman A. Yunes1Marina S. Dukhinova2Maria G. Alekseeva3Valery N. Danilenko4Laboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, RussiaLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, RussiaInternational Institute ‘Solution Chemistry of Advanced Materials and Technologies’, ITMO University, 197101 Saint-Petersburg, RussiaLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, RussiaLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, RussiaBifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human studies. A possible candidate for this role has been discovered recently. The PFNA cluster, consisting of five core genes, <i>pkb2</i>, <i>fn3</i>, <i>aaa-atp</i>, <i>duf58</i>, <i>tgm</i>, has been found in all gut-dwelling autochthonous bifidobacterial species of humans. The sensory region of the species-specific serine-threonine protein kinase (PKB2), the transmembrane region of the microbial transglutaminase (TGM), and the type-III fibronectin domain-containing protein (FN3) encoded by the I gene imply that the PFNA cluster might be implicated in the interaction between bacteria and the host immune system. Moreover, the FN3 protein encoded by one of the genes making up the PFNA cluster, contains domains and motifs of cytokine receptors capable of selectively binding TNF-α. The PFNA cluster could play an important role for sensing signals of the immune system. Among the practical implications of this finding is the creation of anti-inflammatory drugs aimed at alleviating cytokine storms, one of the dire consequences resulting from SARS-CoV-2 infection.https://www.mdpi.com/1422-0067/22/17/9219bifidobacteriaPFNA operonhost-microbe interactionimmune systemevolution |
| spellingShingle | Venera Z. Nezametdinova Roman A. Yunes Marina S. Dukhinova Maria G. Alekseeva Valery N. Danilenko The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 International Journal of Molecular Sciences bifidobacteria PFNA operon host-microbe interaction immune system evolution |
| title | The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 |
| title_full | The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 |
| title_fullStr | The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 |
| title_full_unstemmed | The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 |
| title_short | The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19 |
| title_sort | role of the pfna operon of bifidobacteria in the recognition of host s immune signals prospects for the use of the fn3 protein in the treatment of covid 19 |
| topic | bifidobacteria PFNA operon host-microbe interaction immune system evolution |
| url | https://www.mdpi.com/1422-0067/22/17/9219 |
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