Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans.
Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat st...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4319740?pdf=render |
| _version_ | 1811322911666995200 |
|---|---|
| author | YiHong Ding XiaoJu Zou Xue Jiang JieYu Wu YuRu Zhang Dan Chen Bin Liang |
| author_facet | YiHong Ding XiaoJu Zou Xue Jiang JieYu Wu YuRu Zhang Dan Chen Bin Liang |
| author_sort | YiHong Ding |
| collection | DOAJ |
| description | Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of C. elegans decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage. |
| first_indexed | 2024-04-13T13:44:38Z |
| format | Article |
| id | doaj.art-5a35e6fc305c4b2396086d9b5013d849 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:44:38Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5a35e6fc305c4b2396086d9b5013d8492022-12-22T02:44:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011381510.1371/journal.pone.0113815Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans.YiHong DingXiaoJu ZouXue JiangJieYu WuYuRu ZhangDan ChenBin LiangConsumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of C. elegans decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage.http://europepmc.org/articles/PMC4319740?pdf=render |
| spellingShingle | YiHong Ding XiaoJu Zou Xue Jiang JieYu Wu YuRu Zhang Dan Chen Bin Liang Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. PLoS ONE |
| title | Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. |
| title_full | Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. |
| title_fullStr | Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. |
| title_full_unstemmed | Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. |
| title_short | Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans. |
| title_sort | pu erh tea down regulates sterol regulatory element binding protein and stearyol coa desaturase to reduce fat storage in caenorhaditis elegans |
| url | http://europepmc.org/articles/PMC4319740?pdf=render |
| work_keys_str_mv | AT yihongding puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT xiaojuzou puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT xuejiang puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT jieyuwu puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT yuruzhang puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT danchen puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans AT binliang puerhteadownregulatessterolregulatoryelementbindingproteinandstearyolcoadesaturasetoreducefatstorageincaenorhaditiselegans |