Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats
CONTEXTS: Nonsteroidal anti-inflammatory drugs (NSAIDs) induced organ damage is a well-known fact. Previous studies suggest that Lactobacillus scavenge the free radicals from liver and kidney and also protect animals from arthritis. AIMS: Comparing protective properties of Lactobacillus acidophilus...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2016;volume=9;issue=1;spage=41;epage=46;aulast=Amdekar |
| _version_ | 1818316783905406976 |
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| author | Sarika Amdekar Vinod Singh |
| author_facet | Sarika Amdekar Vinod Singh |
| author_sort | Sarika Amdekar |
| collection | DOAJ |
| description | CONTEXTS: Nonsteroidal anti-inflammatory drugs (NSAIDs) induced organ damage is a well-known fact. Previous studies suggest that Lactobacillus scavenge the free radicals from liver and kidney and also protect animals from arthritis. AIMS: Comparing protective properties of Lactobacillus acidophilus in reducing oxidative stress from reproductive organs developed during collagen-induced arthritis in animal model. METHODS: Arthritis was induced in Wistar rats. Oral administration of L. acidophilus, indomethacin, and distilled water were all started on the same day. Arthritis scores were calculated for each group. Oxidative stress parameters were estimated in testis and ovary homogenates. Histopathology of ovary and testis was also performed. RESULTS AND CONCLUSION: L. acidophilus decreased arthritis score (P < 0.001) as well as maintained normal histology of reproductive organs. L. acidophilus maintained oxidative stress parameters from ovaries and testis (P < 0.001). These results provide strong evidence that NSAIDs increase oxidative stress in reproductive organs while L. acidophilus not only scavenges free radicals from reproductive organs but also protects rats from arthritis symptoms. |
| first_indexed | 2024-12-13T09:26:55Z |
| format | Article |
| id | doaj.art-5a3647bd29bf4371864f1ee8590db329 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-13T09:26:55Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-5a3647bd29bf4371864f1ee8590db3292022-12-21T23:52:35ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662016-01-0191414610.4103/0974-1208.178638Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic ratsSarika AmdekarVinod SinghCONTEXTS: Nonsteroidal anti-inflammatory drugs (NSAIDs) induced organ damage is a well-known fact. Previous studies suggest that Lactobacillus scavenge the free radicals from liver and kidney and also protect animals from arthritis. AIMS: Comparing protective properties of Lactobacillus acidophilus in reducing oxidative stress from reproductive organs developed during collagen-induced arthritis in animal model. METHODS: Arthritis was induced in Wistar rats. Oral administration of L. acidophilus, indomethacin, and distilled water were all started on the same day. Arthritis scores were calculated for each group. Oxidative stress parameters were estimated in testis and ovary homogenates. Histopathology of ovary and testis was also performed. RESULTS AND CONCLUSION: L. acidophilus decreased arthritis score (P < 0.001) as well as maintained normal histology of reproductive organs. L. acidophilus maintained oxidative stress parameters from ovaries and testis (P < 0.001). These results provide strong evidence that NSAIDs increase oxidative stress in reproductive organs while L. acidophilus not only scavenges free radicals from reproductive organs but also protects rats from arthritis symptoms.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2016;volume=9;issue=1;spage=41;epage=46;aulast=AmdekarCollagen-induced arthritiscyclooxygenaseLactobacillus acidophilusovaryoxidative stressprobioticstestis |
| spellingShingle | Sarika Amdekar Vinod Singh Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats Journal of Human Reproductive Sciences Collagen-induced arthritis cyclooxygenase Lactobacillus acidophilus ovary oxidative stress probiotics testis |
| title | Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats |
| title_full | Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats |
| title_fullStr | Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats |
| title_full_unstemmed | Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats |
| title_short | Lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen-induced arthritic rats |
| title_sort | lactobacillus acidophilus maintained oxidative stress from reproductive organs in collagen induced arthritic rats |
| topic | Collagen-induced arthritis cyclooxygenase Lactobacillus acidophilus ovary oxidative stress probiotics testis |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2016;volume=9;issue=1;spage=41;epage=46;aulast=Amdekar |
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