Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis
This study comprehensively evaluated and compared three human rabies vaccines. Seven electronic databases were systematically searched. The Cochrane Handbook v5.1.0 was used to assess the risk of bias. A random-effects model was used to combine individual rates, and network meta-analysis was used fo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2027714 |
| _version_ | 1797673240476254208 |
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| author | Shi-Yuan Wang Jin-Fang Sun Pei Liu Li Luo Jing-Xin Li Feng-Cai Zhu Xu-Xiang Shen Fan-Yue Meng |
| author_facet | Shi-Yuan Wang Jin-Fang Sun Pei Liu Li Luo Jing-Xin Li Feng-Cai Zhu Xu-Xiang Shen Fan-Yue Meng |
| author_sort | Shi-Yuan Wang |
| collection | DOAJ |
| description | This study comprehensively evaluated and compared three human rabies vaccines. Seven electronic databases were systematically searched. The Cochrane Handbook v5.1.0 was used to assess the risk of bias. A random-effects model was used to combine individual rates, and network meta-analysis was used for pairwise comparisons. Twenty-seven articles were included, with a total of 18,630 participants. The pooled incidence of the total adverse reaction to HDCV was significantly lower than that of PCECV. HDCV administration resulted in a lower incidence of local pain, fever, and weakness than purified Vero cell vaccine. HDCV caused a lower incidence of local pain and fever than PCECV. No significant difference was observed in terms of the seroconversion rate on day 7 or the rabies virus-neutralizing antibody titer on day 14. HDCV demonstrated superiority in terms of safety compared with the other two rabies vaccines, while the same was not observed in terms of immunogenicity. |
| first_indexed | 2024-03-11T21:41:38Z |
| format | Article |
| id | doaj.art-5a36d49a729549ee92d57311fd007519 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:41:38Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-5a36d49a729549ee92d57311fd0075192023-09-26T12:55:45ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-01-0118110.1080/21645515.2022.20277142027714Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysisShi-Yuan Wang0Jin-Fang Sun1Pei Liu2Li Luo3Jing-Xin Li4Feng-Cai Zhu5Xu-Xiang Shen6Fan-Yue Meng7Southeast UniversitySoutheast UniversitySoutheast UniversitySoutheast UniversityJiangsu Provincial Center for Disease Control and PreventionSoutheast UniversitySoutheast UniversityJiangsu Provincial Center for Disease Control and PreventionThis study comprehensively evaluated and compared three human rabies vaccines. Seven electronic databases were systematically searched. The Cochrane Handbook v5.1.0 was used to assess the risk of bias. A random-effects model was used to combine individual rates, and network meta-analysis was used for pairwise comparisons. Twenty-seven articles were included, with a total of 18,630 participants. The pooled incidence of the total adverse reaction to HDCV was significantly lower than that of PCECV. HDCV administration resulted in a lower incidence of local pain, fever, and weakness than purified Vero cell vaccine. HDCV caused a lower incidence of local pain and fever than PCECV. No significant difference was observed in terms of the seroconversion rate on day 7 or the rabies virus-neutralizing antibody titer on day 14. HDCV demonstrated superiority in terms of safety compared with the other two rabies vaccines, while the same was not observed in terms of immunogenicity.http://dx.doi.org/10.1080/21645515.2022.2027714rabies vaccinespost-exposure prophylaxisimmunogenicityadverse reactionmeta-analysis |
| spellingShingle | Shi-Yuan Wang Jin-Fang Sun Pei Liu Li Luo Jing-Xin Li Feng-Cai Zhu Xu-Xiang Shen Fan-Yue Meng Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis Human Vaccines & Immunotherapeutics rabies vaccines post-exposure prophylaxis immunogenicity adverse reaction meta-analysis |
| title | Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis |
| title_full | Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis |
| title_fullStr | Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis |
| title_full_unstemmed | Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis |
| title_short | Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis |
| title_sort | immunogenicity and safety of human diploid cell vaccine hdcv vs purified vero cell vaccine pvrv vs purified chick embryo cell vaccine pcecv used in post exposure prophylaxis a systematic review and meta analysis |
| topic | rabies vaccines post-exposure prophylaxis immunogenicity adverse reaction meta-analysis |
| url | http://dx.doi.org/10.1080/21645515.2022.2027714 |
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