Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospective...
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MDPI AG
2021-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/22/5610 |
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| author | Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker |
| author_facet | Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker |
| author_sort | Tim Wende |
| collection | DOAJ |
| description | Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospectively measured in 335 patients with newly diagnosed glioblastoma between 1 January 2014 and 31 December 2019 at the University Hospitals of Leipzig and Rostock. The cohort was dichotomized by TMT and tested for association with overall survival (OS) after 12 months by multivariate proportional hazard calculation. Results: TMT of 7.0 mm or more was associated with increased OS (46.3 ± 3.9% versus 36.6 ± 3.9%, <i>p</i> > 0.001). However, the sub-groups showed significant epidemiological differences. In multivariate proportional hazard calculation, patient age (HR 1.01; <i>p</i> = 0.004), MGMT promoter status (HR 0.76; <i>p</i> = 0.002), EOR (HR 0.61), adjuvant irradiation (HR 0.24) and adjuvant chemotherapy (HR 0.40; all <i>p</i> < 0.001) were independent prognostic markers for OS. However, KPS (HR 1.00, <i>p</i> = 0.31), BMI (HR 0.98, <i>p</i> = 0.11) and TMT (HR 1.06; <i>p</i> = 0.07) were not significantly associated with OS. Conclusion: TMT has not appeared as a statistically independent prognostic marker in this cohort of patients with newly diagnosed IDH-wildtype glioblastoma. |
| first_indexed | 2024-03-10T05:39:17Z |
| format | Article |
| id | doaj.art-5a379d50e8a448e1925c6e300f23406f |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:39:17Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a379d50e8a448e1925c6e300f23406f2023-11-22T22:40:42ZengMDPI AGCancers2072-66942021-11-011322561010.3390/cancers13225610Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter AnalysisTim Wende0Johannes Kasper1Gordian Prasse2Änne Glass3Thomas Kriesen4Thomas M. Freiman5Jürgen Meixensberger6Christian Henker7Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, GermanyInstitute of Biostatistics and Informatics in Medicine, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Medical Center Rostock, 18057 Rostock, GermanyBackground: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospectively measured in 335 patients with newly diagnosed glioblastoma between 1 January 2014 and 31 December 2019 at the University Hospitals of Leipzig and Rostock. The cohort was dichotomized by TMT and tested for association with overall survival (OS) after 12 months by multivariate proportional hazard calculation. Results: TMT of 7.0 mm or more was associated with increased OS (46.3 ± 3.9% versus 36.6 ± 3.9%, <i>p</i> > 0.001). However, the sub-groups showed significant epidemiological differences. In multivariate proportional hazard calculation, patient age (HR 1.01; <i>p</i> = 0.004), MGMT promoter status (HR 0.76; <i>p</i> = 0.002), EOR (HR 0.61), adjuvant irradiation (HR 0.24) and adjuvant chemotherapy (HR 0.40; all <i>p</i> < 0.001) were independent prognostic markers for OS. However, KPS (HR 1.00, <i>p</i> = 0.31), BMI (HR 0.98, <i>p</i> = 0.11) and TMT (HR 1.06; <i>p</i> = 0.07) were not significantly associated with OS. Conclusion: TMT has not appeared as a statistically independent prognostic marker in this cohort of patients with newly diagnosed IDH-wildtype glioblastoma.https://www.mdpi.com/2072-6694/13/22/5610glioblastomatemporal muscle thicknesssurvivalprognostic marker |
| spellingShingle | Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis Cancers glioblastoma temporal muscle thickness survival prognostic marker |
| title | Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis |
| title_full | Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis |
| title_fullStr | Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis |
| title_full_unstemmed | Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis |
| title_short | Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis |
| title_sort | newly diagnosed idh wildtype glioblastoma and temporal muscle thickness a multicenter analysis |
| topic | glioblastoma temporal muscle thickness survival prognostic marker |
| url | https://www.mdpi.com/2072-6694/13/22/5610 |
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