The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy
The tumor microenvironment (TME) is complex and involves many different cell types that seemingly work together in helping cancer cells evade immune monitoring and survive therapy. The advent of single-cell sequencing has greatly increased our knowledge of the cell types present in the tumor microen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/15/12311 |
| _version_ | 1797586598937755648 |
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| author | Mugdha Vijay Patwardhan Ratha Mahendran |
| author_facet | Mugdha Vijay Patwardhan Ratha Mahendran |
| author_sort | Mugdha Vijay Patwardhan |
| collection | DOAJ |
| description | The tumor microenvironment (TME) is complex and involves many different cell types that seemingly work together in helping cancer cells evade immune monitoring and survive therapy. The advent of single-cell sequencing has greatly increased our knowledge of the cell types present in the tumor microenvironment and their role in the developing cancer. This, coupled with clinical data showing that cancer development and the response to therapy may be influenced by drugs that indirectly influence the tumor environment, highlights the need to better understand how the cells present in the TME work together. This review looks at the different cell types (cancer cells, cancer stem cells, endothelial cells, pericytes, adipose cells, cancer-associated fibroblasts, and neuronal cells) in the bladder tumor microenvironment. Their impact on immune activation and on shaping the microenvironment are discussed as well as the effects of hypertensive drugs and anesthetics on bladder cancer. |
| first_indexed | 2024-03-11T00:25:23Z |
| format | Article |
| id | doaj.art-5a3be0cbb605448993a4d223e0b72e8f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:25:23Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5a3be0cbb605448993a4d223e0b72e8f2023-11-18T23:03:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151231110.3390/ijms241512311The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact TherapyMugdha Vijay Patwardhan0Ratha Mahendran1Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeThe tumor microenvironment (TME) is complex and involves many different cell types that seemingly work together in helping cancer cells evade immune monitoring and survive therapy. The advent of single-cell sequencing has greatly increased our knowledge of the cell types present in the tumor microenvironment and their role in the developing cancer. This, coupled with clinical data showing that cancer development and the response to therapy may be influenced by drugs that indirectly influence the tumor environment, highlights the need to better understand how the cells present in the TME work together. This review looks at the different cell types (cancer cells, cancer stem cells, endothelial cells, pericytes, adipose cells, cancer-associated fibroblasts, and neuronal cells) in the bladder tumor microenvironment. Their impact on immune activation and on shaping the microenvironment are discussed as well as the effects of hypertensive drugs and anesthetics on bladder cancer.https://www.mdpi.com/1422-0067/24/15/12311bladder cancertumor microenvironmentsingle cells |
| spellingShingle | Mugdha Vijay Patwardhan Ratha Mahendran The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy International Journal of Molecular Sciences bladder cancer tumor microenvironment single cells |
| title | The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy |
| title_full | The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy |
| title_fullStr | The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy |
| title_full_unstemmed | The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy |
| title_short | The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy |
| title_sort | bladder tumor microenvironment components that modulate the tumor and impact therapy |
| topic | bladder cancer tumor microenvironment single cells |
| url | https://www.mdpi.com/1422-0067/24/15/12311 |
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