GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence

GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence

The present paper summarizes the preclinical and clinical studies conducted to define the anti-alcohol pharmacological profile of the prototypic GABAB receptor agonist, baclofen, and its therapeutic potential for treatment of alcohol use disorder (AUD). Numerous studies have reported baclofen-induce...

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Bibliographic Details
Main Authors:	Roberta eAgabio, Giancarlo eColombo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-06-01
Series:	Frontiers in Neuroscience
Subjects:	Baclofen GABAB receptor alcohol use disorder Positive allosteric modulators Animal models of alcohol use disorder
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00140/full

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