Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis
Abstract Background A factory‐calibrated flash glucose monitoring system (FGMS; FreeStyle Libre) recently was evaluated in dogs with uncomplicated diabetes mellitus. It is not known if this system is reliable during diabetic ketoacidosis (DKA). Objectives To assess the performance of the FGMS in dog...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15657 |
| _version_ | 1818301790285725696 |
|---|---|
| author | Eleonora Malerba Chiara Cattani Francesca Del Baldo Gaia Carotenuto Sara Corradini Stefania Golinelli Ignazio Drudi Federico Fracassi |
| author_facet | Eleonora Malerba Chiara Cattani Francesca Del Baldo Gaia Carotenuto Sara Corradini Stefania Golinelli Ignazio Drudi Federico Fracassi |
| author_sort | Eleonora Malerba |
| collection | DOAJ |
| description | Abstract Background A factory‐calibrated flash glucose monitoring system (FGMS; FreeStyle Libre) recently was evaluated in dogs with uncomplicated diabetes mellitus. It is not known if this system is reliable during diabetic ketoacidosis (DKA). Objectives To assess the performance of the FGMS in dogs with DKA and to determine the effect of severity of ketosis and acidosis, lactate concentration, body condition score (BCS), and time wearing the sensor on the accuracy of the device. Animals Fourteen client‐owned dogs with DKA. Methods The interstitial glucose (IG) measurements were compared with blood glucose (BG) measurements obtained using a validated portable glucometer. The influence of changes in metabolic variables (β‐hydroxybutyrate, pH, bicarbonate, and lactate) and the effect of BCS and time wearing on sensor performance were evaluated. Accuracy was determined by fulfillment of ISO15197:2013 criteria. Results Metabolic variables, BCS, and time wearing were not associated with the accuracy of the sensor. Good agreement between IG measurements and BG was obtained both before and after DKA resolution (r = .88 and r = .93, respectively). Analytical accuracy was not achieved, whereas clinical accuracy was demonstrated with 100% and 99.6% of results in zones A + B of the Parkes consensus error grid analysis before and after DKA resolution, respectively. Conclusions and Clinical Importance Changes in metabolic variables, BCS, and time wearing do not seem to affect agreement between IG and BG. Despite not fulfilling the ISO requirements, the FGMS provides clinically accurate estimates of BG in dogs with DKA. |
| first_indexed | 2024-12-13T05:28:36Z |
| format | Article |
| id | doaj.art-5a3f448fc707449195129a826e76077c |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-13T05:28:36Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-5a3f448fc707449195129a826e76077c2022-12-21T23:58:07ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-01-01341839110.1111/jvim.15657Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosisEleonora Malerba0Chiara Cattani1Francesca Del Baldo2Gaia Carotenuto3Sara Corradini4Stefania Golinelli5Ignazio Drudi6Federico Fracassi7Department of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyDepartment of Statistical Sciences University of Bologna Bologna ItalyDepartment of Veterinary Medical Sciences University of Bologna, Ozzano dell'Emilia Bologna ItalyAbstract Background A factory‐calibrated flash glucose monitoring system (FGMS; FreeStyle Libre) recently was evaluated in dogs with uncomplicated diabetes mellitus. It is not known if this system is reliable during diabetic ketoacidosis (DKA). Objectives To assess the performance of the FGMS in dogs with DKA and to determine the effect of severity of ketosis and acidosis, lactate concentration, body condition score (BCS), and time wearing the sensor on the accuracy of the device. Animals Fourteen client‐owned dogs with DKA. Methods The interstitial glucose (IG) measurements were compared with blood glucose (BG) measurements obtained using a validated portable glucometer. The influence of changes in metabolic variables (β‐hydroxybutyrate, pH, bicarbonate, and lactate) and the effect of BCS and time wearing on sensor performance were evaluated. Accuracy was determined by fulfillment of ISO15197:2013 criteria. Results Metabolic variables, BCS, and time wearing were not associated with the accuracy of the sensor. Good agreement between IG measurements and BG was obtained both before and after DKA resolution (r = .88 and r = .93, respectively). Analytical accuracy was not achieved, whereas clinical accuracy was demonstrated with 100% and 99.6% of results in zones A + B of the Parkes consensus error grid analysis before and after DKA resolution, respectively. Conclusions and Clinical Importance Changes in metabolic variables, BCS, and time wearing do not seem to affect agreement between IG and BG. Despite not fulfilling the ISO requirements, the FGMS provides clinically accurate estimates of BG in dogs with DKA.https://doi.org/10.1111/jvim.15657caninefreestyle libreinterstitial glucosenoninvasive glucose measurement |
| spellingShingle | Eleonora Malerba Chiara Cattani Francesca Del Baldo Gaia Carotenuto Sara Corradini Stefania Golinelli Ignazio Drudi Federico Fracassi Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis Journal of Veterinary Internal Medicine canine freestyle libre interstitial glucose noninvasive glucose measurement |
| title | Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| title_full | Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| title_fullStr | Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| title_full_unstemmed | Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| title_short | Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| title_sort | accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis |
| topic | canine freestyle libre interstitial glucose noninvasive glucose measurement |
| url | https://doi.org/10.1111/jvim.15657 |
| work_keys_str_mv | AT eleonoramalerba accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT chiaracattani accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT francescadelbaldo accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT gaiacarotenuto accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT saracorradini accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT stefaniagolinelli accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT ignaziodrudi accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis AT federicofracassi accuracyofaflashglucosemonitoringsystemindogswithdiabeticketoacidosis |