Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential
Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding capability because of its ability to allow allosteric modulation despite being a monomeric protein. Physiologically, HSA act as the primary carrier for various exogenous and endogenous compounds and fatty acids, an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Structural Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665928X2300020X |
| _version_ | 1797397544482897920 |
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| author | Sajda Ashraf Hina Qaiser Sumayya Tariq Asaad Khalid Hafiz A. Makeen Hassan A. Alhazmi Zaheer Ul-Haq |
| author_facet | Sajda Ashraf Hina Qaiser Sumayya Tariq Asaad Khalid Hafiz A. Makeen Hassan A. Alhazmi Zaheer Ul-Haq |
| author_sort | Sajda Ashraf |
| collection | DOAJ |
| description | Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding capability because of its ability to allow allosteric modulation despite being a monomeric protein. Physiologically, HSA act as the primary carrier for various exogenous and endogenous compounds and fatty acids, and alter the pharmacokinetic properties of several drugs. It has antioxidant properties and is utilized therapeutically to improve the drug delivery of pharmacological agents for the treatment of several disorders. The flexibility of albumin in holding various types of drugs coupled with a variety of modifications makes this protein a versatile drug carrier with incalculable potential in therapeutics. This review provides a brief outline of the different structural properties of HSA, and its various binding sites, moreover, an overview of the genetic, biomedical, and allosteric modulation of drugs and drug delivery aspects of HSA is also included, which may be helpful in guiding advanced clinical applications and further research on the therapeutic potential of this extraordinary protein. |
| first_indexed | 2024-03-09T01:11:34Z |
| format | Article |
| id | doaj.art-5a404135473d4c0b88695f17a125bd8d |
| institution | Directory Open Access Journal |
| issn | 2665-928X |
| language | English |
| last_indexed | 2024-03-09T01:11:34Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Structural Biology |
| spelling | doaj.art-5a404135473d4c0b88695f17a125bd8d2023-12-11T04:17:06ZengElsevierCurrent Research in Structural Biology2665-928X2023-01-016100114Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potentialSajda Ashraf0Hina Qaiser1Sumayya Tariq2Asaad Khalid3Hafiz A. Makeen4Hassan A. Alhazmi5Zaheer Ul-Haq6Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, PakistanDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, PakistanDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, PakistanSubstance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan, Saudi Arabia; Medicinal and Aromatic Plants Research Institute, National Center for Research, P.O. Box: 2424, Khartoum, 11111, SudanPharmacy Practice Research Unit, Clinical Pharmacy Department, Faculty of Pharmacy, Jazan University, Jazan, Saudi ArabiaSubstance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan, Saudi Arabia; Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, 45142, Jazan, Saudi ArabiaDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, Pakistan; Corresponding author.Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding capability because of its ability to allow allosteric modulation despite being a monomeric protein. Physiologically, HSA act as the primary carrier for various exogenous and endogenous compounds and fatty acids, and alter the pharmacokinetic properties of several drugs. It has antioxidant properties and is utilized therapeutically to improve the drug delivery of pharmacological agents for the treatment of several disorders. The flexibility of albumin in holding various types of drugs coupled with a variety of modifications makes this protein a versatile drug carrier with incalculable potential in therapeutics. This review provides a brief outline of the different structural properties of HSA, and its various binding sites, moreover, an overview of the genetic, biomedical, and allosteric modulation of drugs and drug delivery aspects of HSA is also included, which may be helpful in guiding advanced clinical applications and further research on the therapeutic potential of this extraordinary protein.http://www.sciencedirect.com/science/article/pii/S2665928X2300020XHuman serum albuminAllosteric modulationDrug deliveryDrug specificityAlbumin fusion proteins |
| spellingShingle | Sajda Ashraf Hina Qaiser Sumayya Tariq Asaad Khalid Hafiz A. Makeen Hassan A. Alhazmi Zaheer Ul-Haq Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential Current Research in Structural Biology Human serum albumin Allosteric modulation Drug delivery Drug specificity Albumin fusion proteins |
| title | Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential |
| title_full | Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential |
| title_fullStr | Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential |
| title_full_unstemmed | Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential |
| title_short | Unraveling the versatility of human serum albumin – A comprehensive review of its biological significance and therapeutic potential |
| title_sort | unraveling the versatility of human serum albumin a comprehensive review of its biological significance and therapeutic potential |
| topic | Human serum albumin Allosteric modulation Drug delivery Drug specificity Albumin fusion proteins |
| url | http://www.sciencedirect.com/science/article/pii/S2665928X2300020X |
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