Tissue distribution of crizotinib and gemcitabine combination in a patient-derived orthotopic mouse model of pancreatic cancer

Tissue distribution of crizotinib and gemcitabine combination in a patient-derived orthotopic mouse model of pancreatic cancer

Pharmacokinetics focuses on the question whether a drug actually reaches its target in therapeutic concentrations or accumulates elsewhere, potentially causing toxicological or unpredictable side effects. We determined tissue distribution of gemcitabine, an antimetabolite, and crizotinib, a tyrosine...

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Bibliographic Details
Main Authors: Richard J. Honeywell, Amir Avan, Elisa Giovannetti, Godefridus J. Peters
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2016-12-01
Series:ADMET and DMPK
Subjects:
Crizotinib
gemcitabine
tissue distribution
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/335

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