GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy
Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (H<sub>2</sub>S) gas ex...
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MDPI AG
2023-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/10/2443 |
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| author | Xinqiang Liang Mekhrdod S. Kurboniyon Yuanhan Zou Kezong Luo Shuhong Fang Pengle Xia Shufang Ning Litu Zhang Chen Wang |
| author_facet | Xinqiang Liang Mekhrdod S. Kurboniyon Yuanhan Zou Kezong Luo Shuhong Fang Pengle Xia Shufang Ning Litu Zhang Chen Wang |
| author_sort | Xinqiang Liang |
| collection | DOAJ |
| description | Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (H<sub>2</sub>S) gas exhibit cancer-suppressive effects. Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H<sub>2</sub>S signaling molecule release properties for gas therapy. The as-synthesized nanoplatform confined PB nanoparticles in the mesoporous structure of organosilica silica due to electrostatic adsorption. In the case of a GSH overexpressed tumor microenvironment, H<sub>2</sub>S gas was controllably released. And the temperature increases due to the photothermal effects of PB nanoparticles, further enhancing H<sub>2</sub>S release. At the same time, PB nanoparticles with excellent hydrogen peroxide catalytic performance also amplified the efficiency of tumor therapy. Thus, a collective nanoplatform with gas therapy/photothermal therapy/catalytic therapy functionalities shows potential promise in terms of efficient tumor therapy. |
| first_indexed | 2024-03-10T20:58:39Z |
| format | Article |
| id | doaj.art-5a434ddca07041b9baaa8afe0e6c660f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:58:39Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5a434ddca07041b9baaa8afe0e6c660f2023-11-19T17:44:35ZengMDPI AGPharmaceutics1999-49232023-10-011510244310.3390/pharmaceutics15102443GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas TherapyXinqiang Liang0Mekhrdod S. Kurboniyon1Yuanhan Zou2Kezong Luo3Shuhong Fang4Pengle Xia5Shufang Ning6Litu Zhang7Chen Wang8Department of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaNational Academy of Sciences of Tajikistan, Dushanbe 734000, TajikistanDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaTraditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (H<sub>2</sub>S) gas exhibit cancer-suppressive effects. Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H<sub>2</sub>S signaling molecule release properties for gas therapy. The as-synthesized nanoplatform confined PB nanoparticles in the mesoporous structure of organosilica silica due to electrostatic adsorption. In the case of a GSH overexpressed tumor microenvironment, H<sub>2</sub>S gas was controllably released. And the temperature increases due to the photothermal effects of PB nanoparticles, further enhancing H<sub>2</sub>S release. At the same time, PB nanoparticles with excellent hydrogen peroxide catalytic performance also amplified the efficiency of tumor therapy. Thus, a collective nanoplatform with gas therapy/photothermal therapy/catalytic therapy functionalities shows potential promise in terms of efficient tumor therapy.https://www.mdpi.com/1999-4923/15/10/2443gas therapyH<sub>2</sub>SGSH-triggeredPrussian bluedendritic mesoporous organosilica |
| spellingShingle | Xinqiang Liang Mekhrdod S. Kurboniyon Yuanhan Zou Kezong Luo Shuhong Fang Pengle Xia Shufang Ning Litu Zhang Chen Wang GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy Pharmaceutics gas therapy H<sub>2</sub>S GSH-triggered Prussian blue dendritic mesoporous organosilica |
| title | GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy |
| title_full | GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy |
| title_fullStr | GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy |
| title_full_unstemmed | GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy |
| title_short | GSH-Triggered/Photothermal-Enhanced H<sub>2</sub>S Signaling Molecule Release for Gas Therapy |
| title_sort | gsh triggered photothermal enhanced h sub 2 sub s signaling molecule release for gas therapy |
| topic | gas therapy H<sub>2</sub>S GSH-triggered Prussian blue dendritic mesoporous organosilica |
| url | https://www.mdpi.com/1999-4923/15/10/2443 |
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