Diagnostic Accuracy of FibroScan and Factors Affecting Measurements
Evaluating liver steatosis and fibrosis is important for patients with non-alcoholic fatty liver disease. Although liver biopsy and pathological assessment is the gold standard for these conditions, this technique has several disadvantages. The evaluation of steatosis and fibrosis using ultrasound B...
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MDPI AG
2020-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/11/940 |
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| author | Satoshi Oeda Kenichi Tanaka Ayaka Oshima Yasue Matsumoto Eisaburo Sueoka Hirokazu Takahashi |
| author_facet | Satoshi Oeda Kenichi Tanaka Ayaka Oshima Yasue Matsumoto Eisaburo Sueoka Hirokazu Takahashi |
| author_sort | Satoshi Oeda |
| collection | DOAJ |
| description | Evaluating liver steatosis and fibrosis is important for patients with non-alcoholic fatty liver disease. Although liver biopsy and pathological assessment is the gold standard for these conditions, this technique has several disadvantages. The evaluation of steatosis and fibrosis using ultrasound B-mode imaging is qualitative and subjective. The liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) determined using FibroScan are the evidence-based non-invasive measures of liver fibrosis and steatosis, respectively. The LSM and CAP measurements are carried out simultaneously, and the median values of more than ten valid measurements are used to quantify liver fibrosis and steatosis. Here, we demonstrate that the reliability of the LSM depends on the interquartile range to median ratio (IQR/Med), but CAP values do not depend on IQR/Med. In addition, the LSM is affected by inflammation, congestion, and cholestasis in addition to fibrosis, while CAP values are affected by the body mass index in addition to steatosis. We also show that the M probe provides higher LSM values but lower CAP values than the XL probe in the same population. However, there was no statistically significant difference between the diagnostic accuracies of the two probes. These findings are important to understand the reliability of FibroScan measurements and the factors influencing measurement values for all patients. |
| first_indexed | 2024-03-10T14:54:55Z |
| format | Article |
| id | doaj.art-5a435b55a1cf4121a76fa4e4bebd8d32 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T14:54:55Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-5a435b55a1cf4121a76fa4e4bebd8d322023-11-20T20:39:27ZengMDPI AGDiagnostics2075-44182020-11-01101194010.3390/diagnostics10110940Diagnostic Accuracy of FibroScan and Factors Affecting MeasurementsSatoshi Oeda0Kenichi Tanaka1Ayaka Oshima2Yasue Matsumoto3Eisaburo Sueoka4Hirokazu Takahashi5Liver Center, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanDepartment of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, JapanDepartment of Laboratory Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanDepartment of Laboratory Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanDepartment of Laboratory Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanLiver Center, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanEvaluating liver steatosis and fibrosis is important for patients with non-alcoholic fatty liver disease. Although liver biopsy and pathological assessment is the gold standard for these conditions, this technique has several disadvantages. The evaluation of steatosis and fibrosis using ultrasound B-mode imaging is qualitative and subjective. The liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) determined using FibroScan are the evidence-based non-invasive measures of liver fibrosis and steatosis, respectively. The LSM and CAP measurements are carried out simultaneously, and the median values of more than ten valid measurements are used to quantify liver fibrosis and steatosis. Here, we demonstrate that the reliability of the LSM depends on the interquartile range to median ratio (IQR/Med), but CAP values do not depend on IQR/Med. In addition, the LSM is affected by inflammation, congestion, and cholestasis in addition to fibrosis, while CAP values are affected by the body mass index in addition to steatosis. We also show that the M probe provides higher LSM values but lower CAP values than the XL probe in the same population. However, there was no statistically significant difference between the diagnostic accuracies of the two probes. These findings are important to understand the reliability of FibroScan measurements and the factors influencing measurement values for all patients.https://www.mdpi.com/2075-4418/10/11/940non-alcoholic fatty liver diseasehepatic steatosishepatic inflammationtransient elastographyliver stiffness measurementcontrolled attenuation parameter |
| spellingShingle | Satoshi Oeda Kenichi Tanaka Ayaka Oshima Yasue Matsumoto Eisaburo Sueoka Hirokazu Takahashi Diagnostic Accuracy of FibroScan and Factors Affecting Measurements Diagnostics non-alcoholic fatty liver disease hepatic steatosis hepatic inflammation transient elastography liver stiffness measurement controlled attenuation parameter |
| title | Diagnostic Accuracy of FibroScan and Factors Affecting Measurements |
| title_full | Diagnostic Accuracy of FibroScan and Factors Affecting Measurements |
| title_fullStr | Diagnostic Accuracy of FibroScan and Factors Affecting Measurements |
| title_full_unstemmed | Diagnostic Accuracy of FibroScan and Factors Affecting Measurements |
| title_short | Diagnostic Accuracy of FibroScan and Factors Affecting Measurements |
| title_sort | diagnostic accuracy of fibroscan and factors affecting measurements |
| topic | non-alcoholic fatty liver disease hepatic steatosis hepatic inflammation transient elastography liver stiffness measurement controlled attenuation parameter |
| url | https://www.mdpi.com/2075-4418/10/11/940 |
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