Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias

L-dopa-induced dyskinesias (LIDs) are a serious complication of L-dopa therapy for Parkinson's disease. Emerging evidence indicates that the nicotinic cholinergic system plays a role in LIDs, although the pathways and mechanisms are poorly understood. Here we used optogenetics to investigate th...

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Bibliographic Details
Main Authors: Tanuja Bordia, Xiomara A. Perez, Jaime E. Heiss, Danhui Zhang, Maryka Quik
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300419