Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis
<p>Abstract</p> <p>Background</p> <p>Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.</p> <p>Methods</p> <p>I...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://www.translational-medicine.com/content/10/1/96 |
| _version_ | 1818393848745820160 |
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| author | Cai Man-Bo Wang Xiao-Pai Zhang Jia-Xing Han Hui-Qiong Liu Chao-Chun Bei Jin-Xin Peng Ruo-Jun Liang Yi Feng Qi-Sheng Wang Hai-Yun Chen Li-Zhen Fu Sha Kang Tiebang Shao Jian-Yong Zeng Yi-Xin |
| author_facet | Cai Man-Bo Wang Xiao-Pai Zhang Jia-Xing Han Hui-Qiong Liu Chao-Chun Bei Jin-Xin Peng Ruo-Jun Liang Yi Feng Qi-Sheng Wang Hai-Yun Chen Li-Zhen Fu Sha Kang Tiebang Shao Jian-Yong Zeng Yi-Xin |
| author_sort | Cai Man-Bo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.</p> <p>Methods</p> <p>Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen –A (HLA-A) in NPC tissue samples.</p> <p>Results</p> <p>The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A.</p> <p>Conclusions</p> <p>Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.</p> |
| first_indexed | 2024-12-14T05:51:50Z |
| format | Article |
| id | doaj.art-5a44e09c24184e6c8b3e902994b4cb42 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-14T05:51:50Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-5a44e09c24184e6c8b3e902994b4cb422022-12-21T23:14:42ZengBMCJournal of Translational Medicine1479-58762012-05-011019610.1186/1479-5876-10-96Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosisCai Man-BoWang Xiao-PaiZhang Jia-XingHan Hui-QiongLiu Chao-ChunBei Jin-XinPeng Ruo-JunLiang YiFeng Qi-ShengWang Hai-YunChen Li-ZhenFu ShaKang TiebangShao Jian-YongZeng Yi-Xin<p>Abstract</p> <p>Background</p> <p>Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.</p> <p>Methods</p> <p>Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen –A (HLA-A) in NPC tissue samples.</p> <p>Results</p> <p>The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A.</p> <p>Conclusions</p> <p>Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.</p>http://www.translational-medicine.com/content/10/1/96Nasopharyngeal carcinomaHeat shock protein 70ExpressionPrognosis |
| spellingShingle | Cai Man-Bo Wang Xiao-Pai Zhang Jia-Xing Han Hui-Qiong Liu Chao-Chun Bei Jin-Xin Peng Ruo-Jun Liang Yi Feng Qi-Sheng Wang Hai-Yun Chen Li-Zhen Fu Sha Kang Tiebang Shao Jian-Yong Zeng Yi-Xin Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis Journal of Translational Medicine Nasopharyngeal carcinoma Heat shock protein 70 Expression Prognosis |
| title | Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis |
| title_full | Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis |
| title_fullStr | Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis |
| title_full_unstemmed | Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis |
| title_short | Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis |
| title_sort | expression of heat shock protein 70 in nasopharyngeal carcinomas different expression patterns correlate with distinct clinical prognosis |
| topic | Nasopharyngeal carcinoma Heat shock protein 70 Expression Prognosis |
| url | http://www.translational-medicine.com/content/10/1/96 |
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