Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway

Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway

Dexmedetomidine (DEX) is known to provide neuroprotection against cerebral ischemia and reperfusion injury (CIRI), but the exact mechanisms remain unclear. This study was conducted to investigate whether DEX pretreatment conferred neuroprotection against CIRI by inhibiting neuroinflammation through...

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Bibliographic Details
Main Authors:	Huan Liu, Jianli Li, Li Jiang, Jinhua He, Huanhuan Zhang, Keyan Wang
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2022-07-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Dexmedetomidine Cerebral ischemia/reperfusion injury Neuroprotection JAK2/STAT3 signaling pathway Inflammation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100645&tlng=en

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