Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease

Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease

The carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) exerts a neuroprotective effect in neurodegenerative diseases via the activation of signaling pathways related to neurotrophins, and also through inhibiting apoptotic cell death. Here, we demonstrate that Hc-TeTx preserves mo...

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Bibliographic Details
Main Authors: Mireia Herrando-Grabulosa, Caty Casas, Kevin Talbot, José Aguilera
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Toxins
Subjects:
carboxyl-terminal domain of the heavy chain of tetanus toxin
neuroprotection
excitotoxicity
spinal muscular atrophy
amyotrophic lateral sclerosis
Online Access:https://www.mdpi.com/2072-6651/12/10/666

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