The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review
Objective: Studies have shown that gingival crevices may be a significant route for SARS-CoV-2 entry. However, the role of oral health in the acquisition and severity of COVID-19 is not known. Design: A retrospective analysis was performed using electronic health record data from a large urban acade...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
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| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905222000955 |
| _version_ | 1798020027083915264 |
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| author | S. Wadhwa S. Dave M.L. Daily A. Nardone R. Li J. Rosario A. Cantos J. Shah H.H. Lu D.J. McMahon M.T. Yin |
| author_facet | S. Wadhwa S. Dave M.L. Daily A. Nardone R. Li J. Rosario A. Cantos J. Shah H.H. Lu D.J. McMahon M.T. Yin |
| author_sort | S. Wadhwa |
| collection | DOAJ |
| description | Objective: Studies have shown that gingival crevices may be a significant route for SARS-CoV-2 entry. However, the role of oral health in the acquisition and severity of COVID-19 is not known. Design: A retrospective analysis was performed using electronic health record data from a large urban academic medical center between 12/1/2019 and 8/24/2020. A total of 387 COVID-19 positive cases were identified and matched 1:1 by age, sex, and race to 387 controls without COVID-19 diagnoses. Demographics, number of missing teeth and alveolar crestal height were determined from radiographs and medical/dental charts. In a subgroup of 107 cases and controls, we also examined the rate of change in alveolar crestal height. A conditional logistic regression model was utilized to assess association between alveolar crestal height and missing teeth with COVID-19 status and with hospitalization status among COVID-19 cases. Results: Increased alveolar bone loss, OR = 4.302 (2.510 – 7.376), fewer missing teeth, OR = 0.897 (0.835–0.965) and lack of smoking history distinguished COVID-19 cases from controls. After adjusting for time between examinations, cases with COVID-19 had greater alveolar bone loss compared to controls (0.641 ± 0.613 mm vs 0.260 ± 0.631 mm, p < 0.01.) Among cases with COVID-19, increased number of missing teeth OR = 2.1871 (1.146– 4.174) was significantly associated with hospitalization. Conclusions: Alveolar bone loss and missing teeth are positively associated with the acquisition and severity of COVID-19 disease, respectively. |
| first_indexed | 2024-04-11T16:50:56Z |
| format | Article |
| id | doaj.art-5a47fa9ebbb341ce895694a98eda22ec |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-04-11T16:50:56Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-5a47fa9ebbb341ce895694a98eda22ec2022-12-22T04:13:27ZengElsevierSaudi Dental Journal1013-90522022-11-01347596603The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart ReviewS. Wadhwa0S. Dave1M.L. Daily2A. Nardone3R. Li4J. Rosario5A. Cantos6J. Shah7H.H. Lu8D.J. McMahon9M.T. Yin10Division of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USA; Corresponding author at: Division of Growth and Development, Columbia University College of Dental Medicine, 630 West 168th Street, New York, NY 10032, USA.Division of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADivision of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADivision of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADivision of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADivision of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADepartment of Medicine Infectious Disease, Columbia University Irving Medical Center, New York, NY, USADepartment of Medicine Infectious Disease, Columbia University Irving Medical Center, New York, NY, USADivision of Growth and Development, Columbia University College of Dental Medicine, New York, NY, USADepartment of Medicine Infectious Disease, Columbia University Irving Medical Center, New York, NY, USADepartment of Medicine Infectious Disease, Columbia University Irving Medical Center, New York, NY, USAObjective: Studies have shown that gingival crevices may be a significant route for SARS-CoV-2 entry. However, the role of oral health in the acquisition and severity of COVID-19 is not known. Design: A retrospective analysis was performed using electronic health record data from a large urban academic medical center between 12/1/2019 and 8/24/2020. A total of 387 COVID-19 positive cases were identified and matched 1:1 by age, sex, and race to 387 controls without COVID-19 diagnoses. Demographics, number of missing teeth and alveolar crestal height were determined from radiographs and medical/dental charts. In a subgroup of 107 cases and controls, we also examined the rate of change in alveolar crestal height. A conditional logistic regression model was utilized to assess association between alveolar crestal height and missing teeth with COVID-19 status and with hospitalization status among COVID-19 cases. Results: Increased alveolar bone loss, OR = 4.302 (2.510 – 7.376), fewer missing teeth, OR = 0.897 (0.835–0.965) and lack of smoking history distinguished COVID-19 cases from controls. After adjusting for time between examinations, cases with COVID-19 had greater alveolar bone loss compared to controls (0.641 ± 0.613 mm vs 0.260 ± 0.631 mm, p < 0.01.) Among cases with COVID-19, increased number of missing teeth OR = 2.1871 (1.146– 4.174) was significantly associated with hospitalization. Conclusions: Alveolar bone loss and missing teeth are positively associated with the acquisition and severity of COVID-19 disease, respectively.http://www.sciencedirect.com/science/article/pii/S1013905222000955COVID-19CoronavirusBone lossPeriodontal disease(s)/periodontitisPeriodontal tissues/periodontium |
| spellingShingle | S. Wadhwa S. Dave M.L. Daily A. Nardone R. Li J. Rosario A. Cantos J. Shah H.H. Lu D.J. McMahon M.T. Yin The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review Saudi Dental Journal COVID-19 Coronavirus Bone loss Periodontal disease(s)/periodontitis Periodontal tissues/periodontium |
| title | The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review |
| title_full | The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review |
| title_fullStr | The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review |
| title_full_unstemmed | The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review |
| title_short | The Role of Oral Health in the Acquisition and Severity of SARS-CoV-2: A Retrospective Chart Review |
| title_sort | role of oral health in the acquisition and severity of sars cov 2 a retrospective chart review |
| topic | COVID-19 Coronavirus Bone loss Periodontal disease(s)/periodontitis Periodontal tissues/periodontium |
| url | http://www.sciencedirect.com/science/article/pii/S1013905222000955 |
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