Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease
Oligodendrocyte precursor cells (OPCs) are mostly known for their capability to differentiate into oligodendrocytes and myelinate axons. However, they have been observed to frequently interact with cells of the neurovascular unit during development, homeostasis, and under pathological conditions. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/12/1954 |
| _version_ | 1797488912903438336 |
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| author | Friederike Pfeiffer |
| author_facet | Friederike Pfeiffer |
| author_sort | Friederike Pfeiffer |
| collection | DOAJ |
| description | Oligodendrocyte precursor cells (OPCs) are mostly known for their capability to differentiate into oligodendrocytes and myelinate axons. However, they have been observed to frequently interact with cells of the neurovascular unit during development, homeostasis, and under pathological conditions. The functional consequences of these interactions are largely unclear, but are increasingly studied. Although OPCs appear to be a rather homogenous cell population in the central nervous system (CNS), they present with an enormous potential to adapt to their microenvironment. In this review, it is summarized what is known about the various roles of OPC-vascular interactions, and the circumstances under which they have been observed. |
| first_indexed | 2024-03-10T00:10:02Z |
| format | Article |
| id | doaj.art-5a4a6dad4dbe480e857efaca13ccd038 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:02Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5a4a6dad4dbe480e857efaca13ccd0382023-11-23T16:02:06ZengMDPI AGCells2073-44092022-06-011112195410.3390/cells11121954Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and DiseaseFriederike Pfeiffer0Department of Neurophysiology, Institute of Physiology, University of Tübingen, 72074 Tübingen, GermanyOligodendrocyte precursor cells (OPCs) are mostly known for their capability to differentiate into oligodendrocytes and myelinate axons. However, they have been observed to frequently interact with cells of the neurovascular unit during development, homeostasis, and under pathological conditions. The functional consequences of these interactions are largely unclear, but are increasingly studied. Although OPCs appear to be a rather homogenous cell population in the central nervous system (CNS), they present with an enormous potential to adapt to their microenvironment. In this review, it is summarized what is known about the various roles of OPC-vascular interactions, and the circumstances under which they have been observed.https://www.mdpi.com/2073-4409/11/12/1954oligodendrocyte precursor cellvasculaturewhite mattergray matterdemyelinationNG2 |
| spellingShingle | Friederike Pfeiffer Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease Cells oligodendrocyte precursor cell vasculature white matter gray matter demyelination NG2 |
| title | Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease |
| title_full | Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease |
| title_fullStr | Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease |
| title_full_unstemmed | Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease |
| title_short | Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease |
| title_sort | reciprocal interactions between oligodendrocyte precursor cells and the neurovascular unit in health and disease |
| topic | oligodendrocyte precursor cell vasculature white matter gray matter demyelination NG2 |
| url | https://www.mdpi.com/2073-4409/11/12/1954 |
| work_keys_str_mv | AT friederikepfeiffer reciprocalinteractionsbetweenoligodendrocyteprecursorcellsandtheneurovascularunitinhealthanddisease |