Linking Metabolic Reprogramming, Plasticity and Tumor Progression
The specific molecular features of cancer cells that distinguish them from the normal ones are denoted as “hallmarks of cancer”. One of the critical hallmarks of cancer is an altered metabolism which provides tumor cells with energy and structural resources necessary for rapid proliferation. The key...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/4/762 |
| _version_ | 1797396784118497280 |
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| author | Oleg Shuvalov Alexandra Daks Olga Fedorova Alexey Petukhov Nickolai Barlev |
| author_facet | Oleg Shuvalov Alexandra Daks Olga Fedorova Alexey Petukhov Nickolai Barlev |
| author_sort | Oleg Shuvalov |
| collection | DOAJ |
| description | The specific molecular features of cancer cells that distinguish them from the normal ones are denoted as “hallmarks of cancer”. One of the critical hallmarks of cancer is an altered metabolism which provides tumor cells with energy and structural resources necessary for rapid proliferation. The key feature of a cancer-reprogrammed metabolism is its plasticity, allowing cancer cells to better adapt to various conditions and to oppose different therapies. Furthermore, the alterations of metabolic pathways in malignant cells are heterogeneous and are defined by several factors including the tissue of origin, driving mutations, and microenvironment. In the present review, we discuss the key features of metabolic reprogramming and plasticity associated with different stages of tumor, from primary tumors to metastases. We also provide evidence of the successful usage of metabolic drugs in anticancer therapy. Finally, we highlight new promising targets for the development of new metabolic drugs. |
| first_indexed | 2024-03-09T00:57:35Z |
| format | Article |
| id | doaj.art-5a4af549691043f28f76a1c82e93e770 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T00:57:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a4af549691043f28f76a1c82e93e7702023-12-11T16:49:56ZengMDPI AGCancers2072-66942021-02-0113476210.3390/cancers13040762Linking Metabolic Reprogramming, Plasticity and Tumor ProgressionOleg Shuvalov0Alexandra Daks1Olga Fedorova2Alexey Petukhov3Nickolai Barlev4Institute of Cytology RAS, 194064 St-Petersburg, RussiaInstitute of Cytology RAS, 194064 St-Petersburg, RussiaInstitute of Cytology RAS, 194064 St-Petersburg, RussiaInstitute of Cytology RAS, 194064 St-Petersburg, RussiaInstitute of Cytology RAS, 194064 St-Petersburg, RussiaThe specific molecular features of cancer cells that distinguish them from the normal ones are denoted as “hallmarks of cancer”. One of the critical hallmarks of cancer is an altered metabolism which provides tumor cells with energy and structural resources necessary for rapid proliferation. The key feature of a cancer-reprogrammed metabolism is its plasticity, allowing cancer cells to better adapt to various conditions and to oppose different therapies. Furthermore, the alterations of metabolic pathways in malignant cells are heterogeneous and are defined by several factors including the tissue of origin, driving mutations, and microenvironment. In the present review, we discuss the key features of metabolic reprogramming and plasticity associated with different stages of tumor, from primary tumors to metastases. We also provide evidence of the successful usage of metabolic drugs in anticancer therapy. Finally, we highlight new promising targets for the development of new metabolic drugs.https://www.mdpi.com/2072-6694/13/4/762metabolic reprogramingcancer metabolismaerobic glycolysislipid metabolismone-carbon metabolismcancer therapy |
| spellingShingle | Oleg Shuvalov Alexandra Daks Olga Fedorova Alexey Petukhov Nickolai Barlev Linking Metabolic Reprogramming, Plasticity and Tumor Progression Cancers metabolic reprograming cancer metabolism aerobic glycolysis lipid metabolism one-carbon metabolism cancer therapy |
| title | Linking Metabolic Reprogramming, Plasticity and Tumor Progression |
| title_full | Linking Metabolic Reprogramming, Plasticity and Tumor Progression |
| title_fullStr | Linking Metabolic Reprogramming, Plasticity and Tumor Progression |
| title_full_unstemmed | Linking Metabolic Reprogramming, Plasticity and Tumor Progression |
| title_short | Linking Metabolic Reprogramming, Plasticity and Tumor Progression |
| title_sort | linking metabolic reprogramming plasticity and tumor progression |
| topic | metabolic reprograming cancer metabolism aerobic glycolysis lipid metabolism one-carbon metabolism cancer therapy |
| url | https://www.mdpi.com/2072-6694/13/4/762 |
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