Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link
There is evidence of correlation between mild cognitive impairment (MCI) and sarcopenia (SA). However, the influencing factors and the mechanism, such as age-related lipid redistribution, remain unknown. This study aimed to clarify the role of dietary fats and erythrocyte lipids profile combined wit...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5321 |
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| author | Xuan Wang Rong Xiao Hongrui Li Tiantian Li Lizheng Guan Huini Ding Xiaoying Li Huaguang Zheng Kang Yu Ai Zhao Wannian Liang Yuandi Xi |
| author_facet | Xuan Wang Rong Xiao Hongrui Li Tiantian Li Lizheng Guan Huini Ding Xiaoying Li Huaguang Zheng Kang Yu Ai Zhao Wannian Liang Yuandi Xi |
| author_sort | Xuan Wang |
| collection | DOAJ |
| description | There is evidence of correlation between mild cognitive impairment (MCI) and sarcopenia (SA). However, the influencing factors and the mechanism, such as age-related lipid redistribution, remain unknown. This study aimed to clarify the role of dietary fats and erythrocyte lipids profile combined with basal metabolic rate (BMR) in the link between MCI and SA. A total of 1050 participants aged 65 to 85 were divided into control, MCI, SA and MCI and SA groups. Bioelectrical impedance analysis was used to evaluate appendicular lean mass and BMR. Cognition and dietary nutrition were detected by neuropsychological tests and food frequency questionnaires. UHPLC-QExactive-MS/MS and UHPLC-Qtrap-MS/MS were used to conduct the lipidomics analysis. Lower dietary intake of different phospholipids, unsaturated fatty acids and kinds of choline were significantly associated with MCI and SA. Least absolute shrinkage and selection operator, multivariate logistic regression, receiver operating characteristic curve and validation tests provided evidence that specific phospholipids, unsaturated fatty acids and BMR might be the critical factors in the processing of MCI and SA, as well as in their link. The lipidomic analysis observed a clear discrimination of the lipid profiles in the individuals who are in MCI, SA, or MCI and SA, compared with the control. Lower expressions in certain phospholipid species, such as sphingomyelin and phosphatidylethanolamines, decreased phosphatidylcholine with more unsaturated double bonds, lower level of lipids with C20:5 and C20:4, higher level of lipids with C18:2 and lipids with a remodeled length of acyl chain, might be closely related to the link between MCI and SA. Inadequate dietary intake and lower concentrations of the erythrocyte lipid profile of phospholipids and unsaturated fatty acids with a lower level of BMR might be the key points that lead to progress in MCI and SA, as well as in their link. They could be used as the prospective biomarkers for the higher risk of cognitive decline and/or SA in elderly population. |
| first_indexed | 2024-03-09T16:00:17Z |
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| id | doaj.art-5a4b502ab53c451487ce293c489a27e5 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:17Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5a4b502ab53c451487ce293c489a27e52023-11-24T17:09:18ZengMDPI AGNutrients2072-66432022-12-011424532110.3390/nu14245321Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the LinkXuan Wang0Rong Xiao1Hongrui Li2Tiantian Li3Lizheng Guan4Huini Ding5Xiaoying Li6Huaguang Zheng7Kang Yu8Ai Zhao9Wannian Liang10Yuandi Xi11Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Jishuitan Hospital, Beijing 100035, ChinaBeijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaPeking Union Medical College Hospital, Beijing 100730, ChinaWanke School of Public Health, Tsinghua University, Beijing 100190, ChinaWanke School of Public Health, Tsinghua University, Beijing 100190, ChinaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing 100069, ChinaThere is evidence of correlation between mild cognitive impairment (MCI) and sarcopenia (SA). However, the influencing factors and the mechanism, such as age-related lipid redistribution, remain unknown. This study aimed to clarify the role of dietary fats and erythrocyte lipids profile combined with basal metabolic rate (BMR) in the link between MCI and SA. A total of 1050 participants aged 65 to 85 were divided into control, MCI, SA and MCI and SA groups. Bioelectrical impedance analysis was used to evaluate appendicular lean mass and BMR. Cognition and dietary nutrition were detected by neuropsychological tests and food frequency questionnaires. UHPLC-QExactive-MS/MS and UHPLC-Qtrap-MS/MS were used to conduct the lipidomics analysis. Lower dietary intake of different phospholipids, unsaturated fatty acids and kinds of choline were significantly associated with MCI and SA. Least absolute shrinkage and selection operator, multivariate logistic regression, receiver operating characteristic curve and validation tests provided evidence that specific phospholipids, unsaturated fatty acids and BMR might be the critical factors in the processing of MCI and SA, as well as in their link. The lipidomic analysis observed a clear discrimination of the lipid profiles in the individuals who are in MCI, SA, or MCI and SA, compared with the control. Lower expressions in certain phospholipid species, such as sphingomyelin and phosphatidylethanolamines, decreased phosphatidylcholine with more unsaturated double bonds, lower level of lipids with C20:5 and C20:4, higher level of lipids with C18:2 and lipids with a remodeled length of acyl chain, might be closely related to the link between MCI and SA. Inadequate dietary intake and lower concentrations of the erythrocyte lipid profile of phospholipids and unsaturated fatty acids with a lower level of BMR might be the key points that lead to progress in MCI and SA, as well as in their link. They could be used as the prospective biomarkers for the higher risk of cognitive decline and/or SA in elderly population.https://www.mdpi.com/2072-6643/14/24/5321mild cognitive impairmentsarcopeniadietary fatslipid profilelipidomics |
| spellingShingle | Xuan Wang Rong Xiao Hongrui Li Tiantian Li Lizheng Guan Huini Ding Xiaoying Li Huaguang Zheng Kang Yu Ai Zhao Wannian Liang Yuandi Xi Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link Nutrients mild cognitive impairment sarcopenia dietary fats lipid profile lipidomics |
| title | Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link |
| title_full | Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link |
| title_fullStr | Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link |
| title_full_unstemmed | Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link |
| title_short | Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link |
| title_sort | correlation between mild cognitive impairment and sarcopenia the prospective role of lipids and basal metabolic rate in the link |
| topic | mild cognitive impairment sarcopenia dietary fats lipid profile lipidomics |
| url | https://www.mdpi.com/2072-6643/14/24/5321 |
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