Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial
Background and Aim: A state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with <i>ad hoc</i> fortified foods seems an appealing strategy to counteract inflammaging...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3580 |
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| author | Morena Martucci Maria Conte Laura Bucci Enrico Giampieri Cristina Fabbri Maria Giustina Palmas Massimo Izzi Stefano Salvioli Angelo Vittorio Zambrini Carla Orsi Patrizia Brigidi Aurelia Santoro Miriam Capri Daniela Monti Claudio Franceschi |
| author_facet | Morena Martucci Maria Conte Laura Bucci Enrico Giampieri Cristina Fabbri Maria Giustina Palmas Massimo Izzi Stefano Salvioli Angelo Vittorio Zambrini Carla Orsi Patrizia Brigidi Aurelia Santoro Miriam Capri Daniela Monti Claudio Franceschi |
| author_sort | Morena Martucci |
| collection | DOAJ |
| description | Background and Aim: A state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with <i>ad hoc</i> fortified foods seems an appealing strategy to counteract inflammaging. The purpose of this study was to test the efficacy of elderly-tailored fortified milk on inflammaging and different health parameters. Methods: A double-blind randomized cross-over study was performed on forty-eight volunteers aged 63–80 years. The fortified milk was enriched with ω-3 polyunsaturated fatty acids (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA), vitamins (25-hydroxyvitamin D, E, C, B6, B9, B12), and trace elements (zinc, selenium). The two intervention periods lasted for 12 weeks, with a 16-week washout intermission. Results: Compared to placebo, the consumption of fortified milk increased the circulating levels of different micronutrients, including vitamins and the ω-3 index of erythrocyte membranes. Conversely, it reduced the amount of arachidonic acid, homocysteine, and ω-6/ω-3 ratio. Conclusion: Twelve-week daily consumption of <i>ad</i><i>hoc</i> fortified milk has an overall positive impact on different health parameters related to inflammaging in the elderly. |
| first_indexed | 2024-03-10T14:39:53Z |
| format | Article |
| id | doaj.art-5a4d0d747852496cbef82196ad001b24 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:39:53Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5a4d0d747852496cbef82196ad001b242023-11-20T21:54:00ZengMDPI AGNutrients2072-66432020-11-011211358010.3390/nu12113580Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over TrialMorena Martucci0Maria Conte1Laura Bucci2Enrico Giampieri3Cristina Fabbri4Maria Giustina Palmas5Massimo Izzi6Stefano Salvioli7Angelo Vittorio Zambrini8Carla Orsi9Patrizia Brigidi10Aurelia Santoro11Miriam Capri12Daniela Monti13Claudio Franceschi14Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyAlma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, 40126 Bologna, ItalyAlma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, 40126 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Quality, Innovation, Safety, Environment, Granarolo S.p.A., 40057 Bologna, ItalyDepartment of Quality, Innovation, Safety, Environment, Granarolo S.p.A., 40057 Bologna, ItalyUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyBackground and Aim: A state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with <i>ad hoc</i> fortified foods seems an appealing strategy to counteract inflammaging. The purpose of this study was to test the efficacy of elderly-tailored fortified milk on inflammaging and different health parameters. Methods: A double-blind randomized cross-over study was performed on forty-eight volunteers aged 63–80 years. The fortified milk was enriched with ω-3 polyunsaturated fatty acids (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA), vitamins (25-hydroxyvitamin D, E, C, B6, B9, B12), and trace elements (zinc, selenium). The two intervention periods lasted for 12 weeks, with a 16-week washout intermission. Results: Compared to placebo, the consumption of fortified milk increased the circulating levels of different micronutrients, including vitamins and the ω-3 index of erythrocyte membranes. Conversely, it reduced the amount of arachidonic acid, homocysteine, and ω-6/ω-3 ratio. Conclusion: Twelve-week daily consumption of <i>ad</i><i>hoc</i> fortified milk has an overall positive impact on different health parameters related to inflammaging in the elderly.https://www.mdpi.com/2072-6643/12/11/3580agingfortified milkhomocysteineω-6/ω-3 ratioω-3 index |
| spellingShingle | Morena Martucci Maria Conte Laura Bucci Enrico Giampieri Cristina Fabbri Maria Giustina Palmas Massimo Izzi Stefano Salvioli Angelo Vittorio Zambrini Carla Orsi Patrizia Brigidi Aurelia Santoro Miriam Capri Daniela Monti Claudio Franceschi Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial Nutrients aging fortified milk homocysteine ω-6/ω-3 ratio ω-3 index |
| title | Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial |
| title_full | Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial |
| title_fullStr | Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial |
| title_full_unstemmed | Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial |
| title_short | Twelve-Week Daily Consumption of <em>ad hoc</em> Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial |
| title_sort | twelve week daily consumption of em ad hoc em fortified milk with ω 3 d and group b vitamins has a positive impact on inflammaging parameters a randomized cross over trial |
| topic | aging fortified milk homocysteine ω-6/ω-3 ratio ω-3 index |
| url | https://www.mdpi.com/2072-6643/12/11/3580 |
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