Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature
Hereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases. They are rarely seen to occur simultaneously in one individual patient. Here we demonstrate a case of HS associated with CML in this study. The patient is a young female, diagnosed wit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2016-01-01
|
| Series: | Open Medicine |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0040/med-2016-0040.xml?format=INT |
| _version_ | 1819113841823318016 |
|---|---|
| author | Testa Domenico Motta Sergio Marcuccio Giuseppina Paccone Marianna Rocca Aldo Ilardi Gennaro Tafuri Domenico Mesolella Massimo Motta Gaetano |
| author_facet | Testa Domenico Motta Sergio Marcuccio Giuseppina Paccone Marianna Rocca Aldo Ilardi Gennaro Tafuri Domenico Mesolella Massimo Motta Gaetano |
| author_sort | Testa Domenico |
| collection | DOAJ |
| description | Hereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases. They are rarely seen to occur simultaneously in one individual patient. Here we demonstrate a case of HS associated with CML in this study. The patient is a young female, diagnosed with HS in 2005, and was given partial embolization of the splenic artery. She got significant remission after the procedure. In 2008, she was found abnormal in blood routine test, after bone marrow routine, chromosome and fusion gene tests, she was diagnosed with CML (chronic phase). She did not receive regular treatment until 3 months prior, and is currently being treated with Dasatimib. She achieved hematological remission, but had no significant improvement in chromosome and fusion gene figures. Due to her severe condition of hemolysis, a splenectomy or an allogeneic hematopoietic stem cell transplantation is considered. |
| first_indexed | 2024-12-22T04:35:49Z |
| format | Article |
| id | doaj.art-5a4d0dc34eda4da089a89e0fbfa64bdd |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-22T04:35:49Z |
| publishDate | 2016-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-5a4d0dc34eda4da089a89e0fbfa64bdd2022-12-21T18:38:53ZengDe GruyterOpen Medicine2391-54632016-01-0111120821410.1515/med-2016-0040med-2016-0040Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literatureTesta Domenico0Motta Sergio1Marcuccio Giuseppina2Paccone Marianna3Rocca Aldo4Ilardi Gennaro5Tafuri Domenico6Mesolella Massimo7Motta Gaetano8Department of Anesthe-siologic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, ItalyUniversity of Naples Federico II, Department of Otorhi-nolaryngology, Naples, ItalyDepartment of Anesthesio-logic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalyUniversity of Naples Federico II, Pathology Unit, Naples, ItalyDepartment of Sport Sciences and Wellness, University of Naples “Parthenope”, Naples, ItalyDepartment of Neuroscience Reproductive and Dentistry Sciences, Otholaryngology Unit; University of Naples “Federico II”, Naples, ItalyDepartment of Anesthesio-logic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, ItalyHereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases. They are rarely seen to occur simultaneously in one individual patient. Here we demonstrate a case of HS associated with CML in this study. The patient is a young female, diagnosed with HS in 2005, and was given partial embolization of the splenic artery. She got significant remission after the procedure. In 2008, she was found abnormal in blood routine test, after bone marrow routine, chromosome and fusion gene tests, she was diagnosed with CML (chronic phase). She did not receive regular treatment until 3 months prior, and is currently being treated with Dasatimib. She achieved hematological remission, but had no significant improvement in chromosome and fusion gene figures. Due to her severe condition of hemolysis, a splenectomy or an allogeneic hematopoietic stem cell transplantation is considered.http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0040/med-2016-0040.xml?format=INTMalignant Fibrous Hystiocytoma (MFH)CO2 Laser CordectomyVocal Cord CancerGlottic sarcoma |
| spellingShingle | Testa Domenico Motta Sergio Marcuccio Giuseppina Paccone Marianna Rocca Aldo Ilardi Gennaro Tafuri Domenico Mesolella Massimo Motta Gaetano Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature Open Medicine Malignant Fibrous Hystiocytoma (MFH) CO2 Laser Cordectomy Vocal Cord Cancer Glottic sarcoma |
| title | Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature |
| title_full | Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature |
| title_fullStr | Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature |
| title_full_unstemmed | Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature |
| title_short | Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature |
| title_sort | our experience in the treatment of malignant fibrous hystiocytoma of the larynx clinical diagnosis therapeutic approach and review of literature |
| topic | Malignant Fibrous Hystiocytoma (MFH) CO2 Laser Cordectomy Vocal Cord Cancer Glottic sarcoma |
| url | http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0040/med-2016-0040.xml?format=INT |
| work_keys_str_mv | AT testadomenico ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT mottasergio ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT marcucciogiuseppina ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT pacconemarianna ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT roccaaldo ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT ilardigennaro ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT tafuridomenico ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT mesolellamassimo ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature AT mottagaetano ourexperienceinthetreatmentofmalignantfibroushystiocytomaofthelarynxclinicaldiagnosistherapeuticapproachandreviewofliterature |