Contact sites between host organelles and pathogens: boon or bane?
ABSTRACTA microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2023-12-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/msphere.00448-23 |
| _version_ | 1797384671069208576 |
|---|---|
| author | Chahat Mehra Lena Pernas |
| author_facet | Chahat Mehra Lena Pernas |
| author_sort | Chahat Mehra |
| collection | DOAJ |
| description | ABSTRACTA microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite Toxoplasma gondii. We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and Toxoplasma. |
| first_indexed | 2024-03-08T21:40:02Z |
| format | Article |
| id | doaj.art-5a4d64def9be4c12b98a6012208ae40d |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-03-08T21:40:02Z |
| publishDate | 2023-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-5a4d64def9be4c12b98a6012208ae40d2023-12-20T14:01:03ZengAmerican Society for MicrobiologymSphere2379-50422023-12-018610.1128/msphere.00448-23Contact sites between host organelles and pathogens: boon or bane?Chahat Mehra0Lena Pernas1Max Planck Institute for Biology of Ageing, Cologne, GermanyMax Planck Institute for Biology of Ageing, Cologne, GermanyABSTRACTA microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite Toxoplasma gondii. We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and Toxoplasma.https://journals.asm.org/doi/10.1128/msphere.00448-23membranemembrane contact sitesmitochondriaendoplasmic reticulumToxoplasma gondiipathogens |
| spellingShingle | Chahat Mehra Lena Pernas Contact sites between host organelles and pathogens: boon or bane? mSphere membrane membrane contact sites mitochondria endoplasmic reticulum Toxoplasma gondii pathogens |
| title | Contact sites between host organelles and pathogens: boon or bane? |
| title_full | Contact sites between host organelles and pathogens: boon or bane? |
| title_fullStr | Contact sites between host organelles and pathogens: boon or bane? |
| title_full_unstemmed | Contact sites between host organelles and pathogens: boon or bane? |
| title_short | Contact sites between host organelles and pathogens: boon or bane? |
| title_sort | contact sites between host organelles and pathogens boon or bane |
| topic | membrane membrane contact sites mitochondria endoplasmic reticulum Toxoplasma gondii pathogens |
| url | https://journals.asm.org/doi/10.1128/msphere.00448-23 |
| work_keys_str_mv | AT chahatmehra contactsitesbetweenhostorganellesandpathogensboonorbane AT lenapernas contactsitesbetweenhostorganellesandpathogensboonorbane |