The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012
Evidence has shown that liver disease caused by hepatitis viruses can be more aggressive and severe in HIV infected subjects. Therefore, the present cross-sectional study aimed to evaluate the seroprevalence of HDV infection among HIV/HBV co-infected clients in Shiraz, southwest Iran. In this study,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2015-09-01
|
| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ijms.sums.ac.ir/index.php/IJMS/article/view/797 |
| _version_ | 1828851891116703744 |
|---|---|
| author | Mohammad Motamedifar Mohammad Taheri Kamran Bagheri Lankarani Mina Gholami Mahmood Amini Lari Hossein Faramarzi Jamal Sarvari |
| author_facet | Mohammad Motamedifar Mohammad Taheri Kamran Bagheri Lankarani Mina Gholami Mahmood Amini Lari Hossein Faramarzi Jamal Sarvari |
| author_sort | Mohammad Motamedifar |
| collection | DOAJ |
| description | Evidence has shown that liver disease caused by hepatitis viruses can be more aggressive and severe in HIV infected subjects. Therefore, the present cross-sectional study aimed to evaluate the seroprevalence of HDV infection among HIV/HBV co-infected clients in Shiraz, southwest Iran. In this study, 178 patients co-infected with HBV and HIV individuals were enrolled. The diagnosis of HIV infection was documented based on serological assays. The demographic and complementary data were collected by a questionnaire. HBsAg and HDV Ab were detected by commercial quantitative enzyme linked immunosorbent assay kits according to the manufacturer’s instructions. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also measured. The mean age of the participants was 37.4±7.4 years (range 22-63). 175 (98.4 %) patients were male and 3 (1.6 %) were female. Among 178 patients co-infected with HIV/HBV, 35 cases (19.7%, 95% CI: 14%-25%) were anti-HDV positive and 143 (80.3%) were negative for anti-HDV. HDV exposure in HIV/HBV co-infected patients was associated with blood transfusion (P=0.002, OR: 14.3) and prison history (P=0.01, OR: 2.31) but not with age, marital status, unsafe sex contact, and injection drug abuse. Our data showed a relatively high prevalence of HDV infection in HIV infected population in Shiraz, Iran. The high frequency of HDV Ab in patients with blood transfusion and prison history reveals that HDV transmission occurs more frequently in the parental route than sexual contacts; therefore, blood screening for HDV diagnosis in the high-risk group is recommended. |
| first_indexed | 2024-12-12T23:40:53Z |
| format | Article |
| id | doaj.art-5a4d9c5de4d642cfa8341848dc2ec2bd |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-12-12T23:40:53Z |
| publishDate | 2015-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-5a4d9c5de4d642cfa8341848dc2ec2bd2022-12-22T00:07:09ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882015-09-01405448453The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012Mohammad Motamedifar0Mohammad Taheri1Kamran Bagheri Lankarani2Mina Gholami3Mahmood Amini Lari4Hossein Faramarzi5Jamal Sarvari6Shiraz HIV/AIDS Research Center (SHARC), Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranHealth Policy Research Center (HPRC), School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center (SHARC), Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center (SHARC), Shiraz University of Medical Sciences, Shiraz, IranDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranEvidence has shown that liver disease caused by hepatitis viruses can be more aggressive and severe in HIV infected subjects. Therefore, the present cross-sectional study aimed to evaluate the seroprevalence of HDV infection among HIV/HBV co-infected clients in Shiraz, southwest Iran. In this study, 178 patients co-infected with HBV and HIV individuals were enrolled. The diagnosis of HIV infection was documented based on serological assays. The demographic and complementary data were collected by a questionnaire. HBsAg and HDV Ab were detected by commercial quantitative enzyme linked immunosorbent assay kits according to the manufacturer’s instructions. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also measured. The mean age of the participants was 37.4±7.4 years (range 22-63). 175 (98.4 %) patients were male and 3 (1.6 %) were female. Among 178 patients co-infected with HIV/HBV, 35 cases (19.7%, 95% CI: 14%-25%) were anti-HDV positive and 143 (80.3%) were negative for anti-HDV. HDV exposure in HIV/HBV co-infected patients was associated with blood transfusion (P=0.002, OR: 14.3) and prison history (P=0.01, OR: 2.31) but not with age, marital status, unsafe sex contact, and injection drug abuse. Our data showed a relatively high prevalence of HDV infection in HIV infected population in Shiraz, Iran. The high frequency of HDV Ab in patients with blood transfusion and prison history reveals that HDV transmission occurs more frequently in the parental route than sexual contacts; therefore, blood screening for HDV diagnosis in the high-risk group is recommended.http://ijms.sums.ac.ir/index.php/IJMS/article/view/797PrevalenceHepatitis delta virusHIVHepatitis B virus |
| spellingShingle | Mohammad Motamedifar Mohammad Taheri Kamran Bagheri Lankarani Mina Gholami Mahmood Amini Lari Hossein Faramarzi Jamal Sarvari The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 Iranian Journal of Medical Sciences Prevalence Hepatitis delta virus HIV Hepatitis B virus |
| title | The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 |
| title_full | The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 |
| title_fullStr | The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 |
| title_full_unstemmed | The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 |
| title_short | The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012 |
| title_sort | prevalence and risk factors of hepatitis delta virus in hiv hbv co infected patients in shiraz iran 2012 |
| topic | Prevalence Hepatitis delta virus HIV Hepatitis B virus |
| url | http://ijms.sums.ac.ir/index.php/IJMS/article/view/797 |
| work_keys_str_mv | AT mohammadmotamedifar theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT mohammadtaheri theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT kamranbagherilankarani theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT minagholami theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT mahmoodaminilari theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT hosseinfaramarzi theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT jamalsarvari theprevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT mohammadmotamedifar prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT mohammadtaheri prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT kamranbagherilankarani prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT minagholami prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT mahmoodaminilari prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT hosseinfaramarzi prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 AT jamalsarvari prevalenceandriskfactorsofhepatitisdeltavirusinhivhbvcoinfectedpatientsinshiraziran2012 |