Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone <i>N</i>-Methylation as A Useful Tool

Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone <i>N</i>-Methylation as A Useful Tool

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In...

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Bibliographic Details
Main Authors: Yang Li, Wang Li, Zhengshuang Xu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Marine Drugs
Subjects:
backbone <i>N</i>-Methylation
cyclic peptide
cyclic peptidomimetic
permeability
Online Access:https://www.mdpi.com/1660-3397/19/6/311

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