EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection

EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection

Follicular helper T (TFH) cells provide specialized help for B cells to ensure optimal humoral immunity. The histone methyltransferase EZH2, as a chromatin repressor, secures the TFH differentiation by promoting TFH lineage associated gene expression during acute viral infection, including Tcf7 and...

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Bibliographic Details
Main Authors: Yuan Luo, Dan Li, Luoyingzi Xie, Shun Lei, Xiangyu Chen, Cong Wang, Dong Yao, Lin Li, Jingyi Fang, Cheng Chen, Shijie Yuan, Fei Li, Xiaorong Xie, Yan Zhang, Zhirong Li, Li Hu, Jianfang Tang, Lilin Ye, Zhengping Wei, Ran He
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
LCMV
TFH cells
EZH2
DNA methylation
Tcf7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.942465/full

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