Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China
Despite high production and usage, little is known about exposure to bisphenol diglycidyl ethers (BDGEs) and their derivatives in pregnant women and fetuses. In this study, we determined nine BDGEs in 106 paired maternal and cord serum samples collected from e-waste dismantling sites in South of Chi...
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Elsevier
2022-12-01
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| Series: | Eco-Environment & Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772985022000412 |
| _version_ | 1827374871946985472 |
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| author | Bo Zhang Henglin Zhang Xueyuan Bai Tao Zhang Jingchuan Xue Shaoyou Lu Kurunthachalam Kannan |
| author_facet | Bo Zhang Henglin Zhang Xueyuan Bai Tao Zhang Jingchuan Xue Shaoyou Lu Kurunthachalam Kannan |
| author_sort | Bo Zhang |
| collection | DOAJ |
| description | Despite high production and usage, little is known about exposure to bisphenol diglycidyl ethers (BDGEs) and their derivatives in pregnant women and fetuses. In this study, we determined nine BDGEs in 106 paired maternal and cord serum samples collected from e-waste dismantling sites in South of China. Bisphenol A bis (2,3-dihydroxypropyl) glycidyl ether (BADGE·2H2O), bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) glycidyl ether (BADGE·HCl·H2O), and bisphenol F diglycidyl ether (BFDGE) were the major BDGEs, with median concentrations of 0.57, 4.07, and 1.60 ng/mL, respectively, in maternal serum, and of 3.58, 5.61, and 0.61 ng/mL, respectively, in cord serum. The transplacental transfer efficiencies (TTEs) were estimated for BDGEs found in samples, and median values were in the range of 0.98 (BFDGE) to 5.91 (BADGE·2H2O). Our results suggested that passive diffusion plays a role in the placental transfer of BADGE·HCl·H2O and BFDGE, whereas several mechanisms contribute to the high accumulation of BADGE·2H2O in cord serum. Multiple linear regression analysis indicated significant associations between maternal serum concentrations of BDGEs and blood clinical biomarkers, especially those related to liver injuries, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and adenosine deaminase (ADA) (P < 0.05). To our knowledge, this is the first study to report the occurrence of BDGEs in paired maternal–fetal serum samples and provide new insights into prenatal and fetal exposures. The newly discovered TTEs in maternal–fetal pairs contribute to a fuller inventory of the transmission activity of pollutants in the human body, ultimately adding to a more significant comprehensive risk evaluation. |
| first_indexed | 2024-03-08T11:41:22Z |
| format | Article |
| id | doaj.art-5a516b50c64d4190b0f7dd17ae0a233f |
| institution | Directory Open Access Journal |
| issn | 2772-9850 |
| language | English |
| last_indexed | 2024-03-08T11:41:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Eco-Environment & Health |
| spelling | doaj.art-5a516b50c64d4190b0f7dd17ae0a233f2024-01-25T05:24:29ZengElsevierEco-Environment & Health2772-98502022-12-0114244250Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of ChinaBo Zhang0Henglin Zhang1Xueyuan Bai2Tao Zhang3Jingchuan Xue4Shaoyou Lu5Kurunthachalam Kannan6School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSouth China Institute of Environmental Sciences, Ministry of Ecology and Environment of the People’s Republic of China, Guangzhou 510655, ChinaSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China; Corresponding author.Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou 510006, ChinaSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangzhou 510006, ChinaDepartment of Pediatrics, New York University School of Medicine, New York NY10016, USADespite high production and usage, little is known about exposure to bisphenol diglycidyl ethers (BDGEs) and their derivatives in pregnant women and fetuses. In this study, we determined nine BDGEs in 106 paired maternal and cord serum samples collected from e-waste dismantling sites in South of China. Bisphenol A bis (2,3-dihydroxypropyl) glycidyl ether (BADGE·2H2O), bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) glycidyl ether (BADGE·HCl·H2O), and bisphenol F diglycidyl ether (BFDGE) were the major BDGEs, with median concentrations of 0.57, 4.07, and 1.60 ng/mL, respectively, in maternal serum, and of 3.58, 5.61, and 0.61 ng/mL, respectively, in cord serum. The transplacental transfer efficiencies (TTEs) were estimated for BDGEs found in samples, and median values were in the range of 0.98 (BFDGE) to 5.91 (BADGE·2H2O). Our results suggested that passive diffusion plays a role in the placental transfer of BADGE·HCl·H2O and BFDGE, whereas several mechanisms contribute to the high accumulation of BADGE·2H2O in cord serum. Multiple linear regression analysis indicated significant associations between maternal serum concentrations of BDGEs and blood clinical biomarkers, especially those related to liver injuries, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and adenosine deaminase (ADA) (P < 0.05). To our knowledge, this is the first study to report the occurrence of BDGEs in paired maternal–fetal serum samples and provide new insights into prenatal and fetal exposures. The newly discovered TTEs in maternal–fetal pairs contribute to a fuller inventory of the transmission activity of pollutants in the human body, ultimately adding to a more significant comprehensive risk evaluation.http://www.sciencedirect.com/science/article/pii/S2772985022000412Bisphenol diglycidyl ethersMaternal–fetal pairsTransplacental transferExposure |
| spellingShingle | Bo Zhang Henglin Zhang Xueyuan Bai Tao Zhang Jingchuan Xue Shaoyou Lu Kurunthachalam Kannan Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China Eco-Environment & Health Bisphenol diglycidyl ethers Maternal–fetal pairs Transplacental transfer Exposure |
| title | Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China |
| title_full | Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China |
| title_fullStr | Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China |
| title_full_unstemmed | Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China |
| title_short | Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China |
| title_sort | placental transfer of bisphenol diglycidyl ethers bdges and its association with maternal health in a population in south of china |
| topic | Bisphenol diglycidyl ethers Maternal–fetal pairs Transplacental transfer Exposure |
| url | http://www.sciencedirect.com/science/article/pii/S2772985022000412 |
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