Functional Polymorphism in the <i>ADRB3</i> Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder

Functional Polymorphism in the <i>ADRB3</i> Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder

Background: There are reports suggesting an association between the rs4994 polymorphism in the <i>ADRB3</i> gene encoding the beta-3 adrenergic receptor and OAB risk in females. The injection of botulinum toxin-A into the bladder wall is recommended as a possible treatment for OAB patien...

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Bibliographic Details
Main Authors: Sylwester Michał Ciećwież, Klaudyna Lewandowska, Agnieszka Boroń, Jacek Brodowski, Jacek Kociszewski, Jeremy Simon Clark, Andrzej Ciechanowicz
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Journal of Clinical Medicine
Subjects:
beta-3 adrenoreceptor
botulinum neurotoxin-A
gene polymorphism
overactive bladder
Online Access:https://www.mdpi.com/2077-0383/11/24/7491
Description
Summary:Background: There are reports suggesting an association between the rs4994 polymorphism in the <i>ADRB3</i> gene encoding the beta-3 adrenergic receptor and OAB risk in females. The injection of botulinum toxin-A into the bladder wall is recommended as a possible treatment for OAB patients in whom first-line therapies have failed. The aim of our study was to analyze the possible association between the <i>ADRB3</i>:rs4994 polymorphism and the patient-perceived response to a single intra-detrusor injection of botulinum toxin-A in Polish women with overactive bladder. Methods: The study group consisted of 115 consecutive female patients with OAB. The response to botulinum toxin-A was evaluated at three months after injection, as absolute or relative reductions in OAB symptoms or in scores from questionnaires ICIQ-OAB (parts A and B) and ICIQ-LUTS-QoL (parts A and B). <i>ADRB3</i>:rs4994 variants were identified by the sequencing of genomic DNA extracted from buccal swabs. Results: There were no statistically significant differences between <i>ADRB3</i>:rs4994 [T];[T] homozygotes and [T];[C]+[C];[C] subjects for absolute or relative reductions in symptoms or in scores from all four questionnaire parts at three months after the injection of botulinum toxin-A. Conclusions: Our results do not support the hypothesis that <i>ADRB3</i>:rs4994 polymorphism is associated with the response to the intra-detrusor injection of botulinum toxin-A in Polish females with overactive bladder.
ISSN:2077-0383

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