Association between SUMF1 polymorphisms and COVID-19 severity
Abstract Background Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COV...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Genomic Data |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12863-023-01133-6 |
| _version_ | 1797795450067091456 |
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| author | Shaohui Liang Huixia Gao Tongxin He Li Li Xin Zhang Lei Zhao Jie Chen Yanyan Xie Jie Bao Yong Gao Erhei Dai Yuling Wang |
| author_facet | Shaohui Liang Huixia Gao Tongxin He Li Li Xin Zhang Lei Zhao Jie Chen Yanyan Xie Jie Bao Yong Gao Erhei Dai Yuling Wang |
| author_sort | Shaohui Liang |
| collection | DOAJ |
| description | Abstract Background Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19. Results We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44–0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90–0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model). Conclusions In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19. |
| first_indexed | 2024-03-13T03:18:06Z |
| format | Article |
| id | doaj.art-5a531994e2cc49e9b56402138a4a3f58 |
| institution | Directory Open Access Journal |
| issn | 2730-6844 |
| language | English |
| last_indexed | 2024-03-13T03:18:06Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomic Data |
| spelling | doaj.art-5a531994e2cc49e9b56402138a4a3f582023-06-25T11:30:35ZengBMCBMC Genomic Data2730-68442023-06-0124111010.1186/s12863-023-01133-6Association between SUMF1 polymorphisms and COVID-19 severityShaohui Liang0Huixia Gao1Tongxin He2Li Li3Xin Zhang4Lei Zhao5Jie Chen6Yanyan Xie7Jie Bao8Yong Gao9Erhei Dai10Yuling Wang11Department of Respiratory, Hebei Chest HospitalDepartment of Laboratory Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityCollege of Plant Protection, Hunan Agricultural UniversityIntensive Care Unit, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityDepartment of Tuberculosis, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityThe Second Internal Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityGraduate School of Hebei Medical UniversityGraduate School of Hebei Medical UniversityDepartment of Respiratory, Hebei Chest HospitalDepartment of Respiratory, Hebei Chest HospitalDepartment of Laboratory Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityDepartment of Tuberculosis, The Fifth Hospital of Shijiazhuang, Hebei Medical UniversityAbstract Background Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19. Results We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44–0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90–0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model). Conclusions In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.https://doi.org/10.1186/s12863-023-01133-6COVID-19Multiple sclerosisSUMF1rs794185 |
| spellingShingle | Shaohui Liang Huixia Gao Tongxin He Li Li Xin Zhang Lei Zhao Jie Chen Yanyan Xie Jie Bao Yong Gao Erhei Dai Yuling Wang Association between SUMF1 polymorphisms and COVID-19 severity BMC Genomic Data COVID-19 Multiple sclerosis SUMF1 rs794185 |
| title | Association between SUMF1 polymorphisms and COVID-19 severity |
| title_full | Association between SUMF1 polymorphisms and COVID-19 severity |
| title_fullStr | Association between SUMF1 polymorphisms and COVID-19 severity |
| title_full_unstemmed | Association between SUMF1 polymorphisms and COVID-19 severity |
| title_short | Association between SUMF1 polymorphisms and COVID-19 severity |
| title_sort | association between sumf1 polymorphisms and covid 19 severity |
| topic | COVID-19 Multiple sclerosis SUMF1 rs794185 |
| url | https://doi.org/10.1186/s12863-023-01133-6 |
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