Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2015-09-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/17872 |
| _version_ | 1797946771334234112 |
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| author | Guilherme Vieira de Castro Carlos Murilo Romero Rocha Vitor Lacerda Sanches Pedro H. Zana Ribeiro Paulo Marcos Donate Rosangela da Silva de Laurentiz Igor Polikarpov Mirela Ines Sairre |
| author_facet | Guilherme Vieira de Castro Carlos Murilo Romero Rocha Vitor Lacerda Sanches Pedro H. Zana Ribeiro Paulo Marcos Donate Rosangela da Silva de Laurentiz Igor Polikarpov Mirela Ines Sairre |
| author_sort | Guilherme Vieira de Castro |
| collection | DOAJ |
| description | Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.
DOI: http://dx.doi.org/10.17807/orbital.v7i3.739
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| first_indexed | 2024-04-10T21:17:23Z |
| format | Article |
| id | doaj.art-5a53eea1ba9e47d088bed456eed08f45 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:23Z |
| publishDate | 2015-09-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-5a53eea1ba9e47d088bed456eed08f452023-01-20T11:03:35ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282015-09-0173Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor ModulatorsGuilherme Vieira de Castro0Carlos Murilo Romero Rocha1Vitor Lacerda Sanches2Pedro H. Zana Ribeiro3Paulo Marcos Donate4Rosangela da Silva de Laurentiz5Igor Polikarpov6Mirela Ines Sairre7Federal University of ABCDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São PauloDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São PauloDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São PauloDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São PauloDepartamento de Física e Química, Faculdade de Engenharia, Universidade Estadual PaulistaDepartamento de Física e Informática, Instituto de Física de São Carlos, Universidade de São PauloFederal University of ABCThyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology. DOI: http://dx.doi.org/10.17807/orbital.v7i3.739 https://periodicos.ufms.br/index.php/orbital/article/view/17872thyroid hormonesnuclear receptorligandssynthesis |
| spellingShingle | Guilherme Vieira de Castro Carlos Murilo Romero Rocha Vitor Lacerda Sanches Pedro H. Zana Ribeiro Paulo Marcos Donate Rosangela da Silva de Laurentiz Igor Polikarpov Mirela Ines Sairre Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators Orbital: The Electronic Journal of Chemistry thyroid hormones nuclear receptor ligands synthesis |
| title | Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
| title_full | Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
| title_fullStr | Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
| title_full_unstemmed | Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
| title_short | Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators |
| title_sort | synthesis of analogues of thyroid hormones nuclear receptor modulators |
| topic | thyroid hormones nuclear receptor ligands synthesis |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/17872 |
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