Modulation of Extracellular Matrix Composition and Chronic Inflammation with Pirfenidone Promotes Scar Reduction in Retinal Wound Repair

Modulation of Extracellular Matrix Composition and Chronic Inflammation with Pirfenidone Promotes Scar Reduction in Retinal Wound Repair

Wound repair in the retina is a complex mechanism, and a deeper understanding of it is necessary for the development of effective treatments to slow down or even prevent degenerative processes leading to photoreceptor loss. In this study, we harnessed a laser-induced retinal degeneration model (532-...

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Bibliographic Details
Main Authors: Laura Jahnke, Virginie Perrenoud, Souska Zandi, Yuebing Li, Federica Maria Conedera, Volker Enzmann
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
retina degeneration
wound repair
extracellular matrix
pirfenidone
fibrosis
inflammation
Online Access:https://www.mdpi.com/2073-4409/13/2/164

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