Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
Introduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 amo...
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Format: | Article |
Language: | English |
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Tabriz University of Medical Sciences Press
2022-07-01
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Series: | Journal of Research in Clinical Medicine |
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Online Access: | https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdf |
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author | Reema Kapoor Mehra Prakriti Gupta Navpreet Singh |
author_facet | Reema Kapoor Mehra Prakriti Gupta Navpreet Singh |
author_sort | Reema Kapoor Mehra |
collection | DOAJ |
description | Introduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 among the Indian population. Methods: The study consisted of 730 patients admitted to Jaya Arogya Hospital, Gwalior, with COVID-19 from August 2020 to December 2020. The patients were divided into mild disease group (MDG) (n=533) and severe disease group (SDG) (n=197) depending on certain criteria, and their biochemical and inflammatory markers were collected. Data were analyzed using SPSS version 25. Results: Statistically significant rise in blood urea (P=0.011), serum creatinine (P=0.008), serum bilirubin (P=0.012), interleukin 6 (IL-6) (P<0.001), and troponin I (P<0.001) was observed in SDG as compared to MDG. Serum electrolytes (sodium and potassium) and serum protein (total protein and albumin) showed a significant fall in SDG as compared to MDG (P<0.001 for electrolytes and P=0.023 for proteins). The area under the receiver operating characteristic curve (AUROC) showed a high diagnostic value of IL-6. Conclusion: Patients with severe COVID-19 showed a high prevalence of hyperbilirubinemia, hypoproteinemia, electrolyte imbalance, and raised inflammatory markers (IL-6, troponin I, and procalcitonin). Results showed their effectiveness in assessing disease severity and predicting outcomes in patients with COVID-19. |
first_indexed | 2024-04-10T07:11:47Z |
format | Article |
id | doaj.art-5a596dcb72e843b2a59152122821fca1 |
institution | Directory Open Access Journal |
issn | 2717-0616 |
language | English |
last_indexed | 2024-04-10T07:11:47Z |
publishDate | 2022-07-01 |
publisher | Tabriz University of Medical Sciences Press |
record_format | Article |
series | Journal of Research in Clinical Medicine |
spelling | doaj.art-5a596dcb72e843b2a59152122821fca12023-02-26T10:24:07ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162022-07-01101101010.34172/jrcm.2022.010jrcm-32076Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational studyReema Kapoor Mehra0Prakriti Gupta1Navpreet Singh2Department of Biochemistry, GRMC Gwalior, Gwalior, Madhya Pradesh – 474011, IndiaDepartment of Pathology, GRMC Gwalior, Gwalior, Madhya Pradesh – 474011, IndiaDepartment of Community and Family Medicine, AIIMS Bilaspur, Himachal Pradeshs – 174001, IndiaIntroduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 among the Indian population. Methods: The study consisted of 730 patients admitted to Jaya Arogya Hospital, Gwalior, with COVID-19 from August 2020 to December 2020. The patients were divided into mild disease group (MDG) (n=533) and severe disease group (SDG) (n=197) depending on certain criteria, and their biochemical and inflammatory markers were collected. Data were analyzed using SPSS version 25. Results: Statistically significant rise in blood urea (P=0.011), serum creatinine (P=0.008), serum bilirubin (P=0.012), interleukin 6 (IL-6) (P<0.001), and troponin I (P<0.001) was observed in SDG as compared to MDG. Serum electrolytes (sodium and potassium) and serum protein (total protein and albumin) showed a significant fall in SDG as compared to MDG (P<0.001 for electrolytes and P=0.023 for proteins). The area under the receiver operating characteristic curve (AUROC) showed a high diagnostic value of IL-6. Conclusion: Patients with severe COVID-19 showed a high prevalence of hyperbilirubinemia, hypoproteinemia, electrolyte imbalance, and raised inflammatory markers (IL-6, troponin I, and procalcitonin). Results showed their effectiveness in assessing disease severity and predicting outcomes in patients with COVID-19.https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdfbiochemical profilecovid-19indiainflammatory markers |
spellingShingle | Reema Kapoor Mehra Prakriti Gupta Navpreet Singh Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study Journal of Research in Clinical Medicine biochemical profile covid-19 india inflammatory markers |
title | Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study |
title_full | Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study |
title_fullStr | Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study |
title_full_unstemmed | Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study |
title_short | Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study |
title_sort | role of biochemical and inflammatory markers in assessing covid 19 severity among the indian population an observational study |
topic | biochemical profile covid-19 india inflammatory markers |
url | https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdf |
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