Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study

Introduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 amo...

Full description

Bibliographic Details
Main Authors: Reema Kapoor Mehra, Prakriti Gupta, Navpreet Singh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences Press 2022-07-01
Series:Journal of Research in Clinical Medicine
Subjects:
Online Access:https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdf
_version_ 1797894592646873088
author Reema Kapoor Mehra
Prakriti Gupta
Navpreet Singh
author_facet Reema Kapoor Mehra
Prakriti Gupta
Navpreet Singh
author_sort Reema Kapoor Mehra
collection DOAJ
description Introduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 among the Indian population. Methods: The study consisted of 730 patients admitted to Jaya Arogya Hospital, Gwalior, with COVID-19 from August 2020 to December 2020. The patients were divided into mild disease group (MDG) (n=533) and severe disease group (SDG) (n=197) depending on certain criteria, and their biochemical and inflammatory markers were collected. Data were analyzed using SPSS version 25. Results: Statistically significant rise in blood urea (P=0.011), serum creatinine (P=0.008), serum bilirubin (P=0.012), interleukin 6 (IL-6) (P<0.001), and troponin I (P<0.001) was observed in SDG as compared to MDG. Serum electrolytes (sodium and potassium) and serum protein (total protein and albumin) showed a significant fall in SDG as compared to MDG (P<0.001 for electrolytes and P=0.023 for proteins). The area under the receiver operating characteristic curve (AUROC) showed a high diagnostic value of IL-6. Conclusion: Patients with severe COVID-19 showed a high prevalence of hyperbilirubinemia, hypoproteinemia, electrolyte imbalance, and raised inflammatory markers (IL-6, troponin I, and procalcitonin). Results showed their effectiveness in assessing disease severity and predicting outcomes in patients with COVID-19.
first_indexed 2024-04-10T07:11:47Z
format Article
id doaj.art-5a596dcb72e843b2a59152122821fca1
institution Directory Open Access Journal
issn 2717-0616
language English
last_indexed 2024-04-10T07:11:47Z
publishDate 2022-07-01
publisher Tabriz University of Medical Sciences Press
record_format Article
series Journal of Research in Clinical Medicine
spelling doaj.art-5a596dcb72e843b2a59152122821fca12023-02-26T10:24:07ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162022-07-01101101010.34172/jrcm.2022.010jrcm-32076Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational studyReema Kapoor Mehra0Prakriti Gupta1Navpreet Singh2Department of Biochemistry, GRMC Gwalior, Gwalior, Madhya Pradesh – 474011, IndiaDepartment of Pathology, GRMC Gwalior, Gwalior, Madhya Pradesh – 474011, IndiaDepartment of Community and Family Medicine, AIIMS Bilaspur, Himachal Pradeshs – 174001, IndiaIntroduction: Different laboratory parameters get altered in coronavirus disease 2019 (COVID-19); therefore, the changes of these parameters could help recognize the patients with severe disease. This study was conducted to achieve a comprehensive biochemical and inflammatory profile of COVID-19 among the Indian population. Methods: The study consisted of 730 patients admitted to Jaya Arogya Hospital, Gwalior, with COVID-19 from August 2020 to December 2020. The patients were divided into mild disease group (MDG) (n=533) and severe disease group (SDG) (n=197) depending on certain criteria, and their biochemical and inflammatory markers were collected. Data were analyzed using SPSS version 25. Results: Statistically significant rise in blood urea (P=0.011), serum creatinine (P=0.008), serum bilirubin (P=0.012), interleukin 6 (IL-6) (P<0.001), and troponin I (P<0.001) was observed in SDG as compared to MDG. Serum electrolytes (sodium and potassium) and serum protein (total protein and albumin) showed a significant fall in SDG as compared to MDG (P<0.001 for electrolytes and P=0.023 for proteins). The area under the receiver operating characteristic curve (AUROC) showed a high diagnostic value of IL-6. Conclusion: Patients with severe COVID-19 showed a high prevalence of hyperbilirubinemia, hypoproteinemia, electrolyte imbalance, and raised inflammatory markers (IL-6, troponin I, and procalcitonin). Results showed their effectiveness in assessing disease severity and predicting outcomes in patients with COVID-19.https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdfbiochemical profilecovid-19indiainflammatory markers
spellingShingle Reema Kapoor Mehra
Prakriti Gupta
Navpreet Singh
Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
Journal of Research in Clinical Medicine
biochemical profile
covid-19
india
inflammatory markers
title Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
title_full Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
title_fullStr Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
title_full_unstemmed Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
title_short Role of biochemical and inflammatory markers in assessing COVID-19 severity among the Indian population: An observational study
title_sort role of biochemical and inflammatory markers in assessing covid 19 severity among the indian population an observational study
topic biochemical profile
covid-19
india
inflammatory markers
url https://jrcm.tbzmed.ac.ir/PDF/jrcm-10-10.pdf
work_keys_str_mv AT reemakapoormehra roleofbiochemicalandinflammatorymarkersinassessingcovid19severityamongtheindianpopulationanobservationalstudy
AT prakritigupta roleofbiochemicalandinflammatorymarkersinassessingcovid19severityamongtheindianpopulationanobservationalstudy
AT navpreetsingh roleofbiochemicalandinflammatorymarkersinassessingcovid19severityamongtheindianpopulationanobservationalstudy