The Natural Product Andrographolide Ameliorates Calcific Aortic Valve Disease by Regulating the Proliferation of Valve Interstitial Cells via the MAPK-ERK Pathway

The Natural Product Andrographolide Ameliorates Calcific Aortic Valve Disease by Regulating the Proliferation of Valve Interstitial Cells via the MAPK-ERK Pathway

Calcific aortic valve disease (CAVD) is an active pathobiological process that involves fibrosis and calcification of aortic valve leaflets, thereby causing cardiac hemodynamic changes and eventually heart failure. Cell proliferation changes at the initial stage of CAVD are an important target for p...

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Bibliographic Details
Main Authors: Yuming Huang, Ming Liu, Chungeng Liu, Nianguo Dong, Liang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
CAVD
andrographolide
cell proliferation
valve interstitial cell
MAPK /ERK2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.871748/full

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