The chemokine receptor CXCR4 is associated with the staging of gastric cancer
Background: CXCR4 is a cognitive receptor for stromal-derived factor-1 (SDF-1) and has been previously shown to be associated with tumor growth and invasion of many cancers. However, its expression and function in gastric cancer has not been well clarified. Materials and Methods: Herein, we studied...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=16;epage=16;aulast=Nikzaban |
| _version_ | 1818180613565317120 |
|---|---|
| author | Mehrnoush Nikzaban Mohammad Said Hakhamaneshi Shohreh Fakhari Farshad Sheikhesmaili Daem Roshani Behzad Ahsan Fatemeh Kamali Ali Jalili |
| author_facet | Mehrnoush Nikzaban Mohammad Said Hakhamaneshi Shohreh Fakhari Farshad Sheikhesmaili Daem Roshani Behzad Ahsan Fatemeh Kamali Ali Jalili |
| author_sort | Mehrnoush Nikzaban |
| collection | DOAJ |
| description | Background: CXCR4 is a cognitive receptor for stromal-derived factor-1 (SDF-1) and has been previously shown to be associated with tumor growth and invasion of many cancers. However, its expression and function in gastric cancer has not been well clarified.
Materials and Methods: Herein, we studied the expression of CXCR4 on gastric samples from patients with gastric adenocarcinoma in comparison with precancerous lesions by employing qRT-PCR.
Results: Our qRT-PCR data show that CXCR4 is highly expressed in tissue samples from patients with gastric cancer than precancerous lesions (2.4 times higher, P value < 0.05). When we correlated the level of CXCR4 with clinicopathological findings, we observed that CXCR4 level is associated with staging of the disease and lymphatic invasion.
In conclusion: We present evidence that CXCR4 level is significantly elevated in later stages of gastric cancer. Thus, CXCR4 may play a crucial role in gastric cancer progression. |
| first_indexed | 2024-12-11T21:22:33Z |
| format | Article |
| id | doaj.art-5a5bc49d497a4fffb12feb3dd0784690 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-11T21:22:33Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-5a5bc49d497a4fffb12feb3dd07846902022-12-22T00:50:25ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752014-01-0131161610.4103/2277-9175.124645The chemokine receptor CXCR4 is associated with the staging of gastric cancerMehrnoush NikzabanMohammad Said HakhamaneshiShohreh FakhariFarshad SheikhesmailiDaem RoshaniBehzad AhsanFatemeh KamaliAli JaliliBackground: CXCR4 is a cognitive receptor for stromal-derived factor-1 (SDF-1) and has been previously shown to be associated with tumor growth and invasion of many cancers. However, its expression and function in gastric cancer has not been well clarified. Materials and Methods: Herein, we studied the expression of CXCR4 on gastric samples from patients with gastric adenocarcinoma in comparison with precancerous lesions by employing qRT-PCR. Results: Our qRT-PCR data show that CXCR4 is highly expressed in tissue samples from patients with gastric cancer than precancerous lesions (2.4 times higher, P value < 0.05). When we correlated the level of CXCR4 with clinicopathological findings, we observed that CXCR4 level is associated with staging of the disease and lymphatic invasion. In conclusion: We present evidence that CXCR4 level is significantly elevated in later stages of gastric cancer. Thus, CXCR4 may play a crucial role in gastric cancer progression.http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=16;epage=16;aulast=NikzabanCXCR4gastric cancerSDF-1 |
| spellingShingle | Mehrnoush Nikzaban Mohammad Said Hakhamaneshi Shohreh Fakhari Farshad Sheikhesmaili Daem Roshani Behzad Ahsan Fatemeh Kamali Ali Jalili The chemokine receptor CXCR4 is associated with the staging of gastric cancer Advanced Biomedical Research CXCR4 gastric cancer SDF-1 |
| title | The chemokine receptor CXCR4 is associated with the staging of gastric cancer |
| title_full | The chemokine receptor CXCR4 is associated with the staging of gastric cancer |
| title_fullStr | The chemokine receptor CXCR4 is associated with the staging of gastric cancer |
| title_full_unstemmed | The chemokine receptor CXCR4 is associated with the staging of gastric cancer |
| title_short | The chemokine receptor CXCR4 is associated with the staging of gastric cancer |
| title_sort | chemokine receptor cxcr4 is associated with the staging of gastric cancer |
| topic | CXCR4 gastric cancer SDF-1 |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=16;epage=16;aulast=Nikzaban |
| work_keys_str_mv | AT mehrnoushnikzaban thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT mohammadsaidhakhamaneshi thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT shohrehfakhari thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT farshadsheikhesmaili thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT daemroshani thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT behzadahsan thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT fatemehkamali thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT alijalili thechemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT mehrnoushnikzaban chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT mohammadsaidhakhamaneshi chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT shohrehfakhari chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT farshadsheikhesmaili chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT daemroshani chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT behzadahsan chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT fatemehkamali chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer AT alijalili chemokinereceptorcxcr4isassociatedwiththestagingofgastriccancer |